新型吡唑基吡啶衍生物的合成及催化Suzuki偶联反应  

Synthesis of novel pyrazolyl pyridine and its catalytic performance for Suzuki coupling reaction

作　　者：张仕禄[1] 赵波[1] 秦大斌[2] 罗杰伟[1] Zhang Shilu;Zhao Bo;Qin Dabin;Luo Jiewei(Analysis Center,North Sichuan Medical College,Nanchong 637100,Sichuan,China;Chemistry and Chemical Engineering,China West Normal University,Nanchong 637002,Sichuan,China)

机构地区：[1]川北医学院分析中心,四川南充637100 [2]西华师范大学化学化工学院,四川南充637002

出　　处：《工业催化》2019年第1期62-66,共5页Industrial Catalysis

基　　金：四川省科技厅资助项目(2017063);川北医学院2018年开放性实验

摘　　要：以4-苯基苯酚和4-叔丁基苯酚为原料设计合成杯芳烃片段桥连的吡唑基吡啶衍生物L1、L2,并采用1H NMR、13C NMR对其结构进行表征。结果表明,化合物L1作为配体,V (DMF)∶V (水)=2:1为溶剂,在80℃时对钯催化Suzuki偶联反应有良好的促进作用。Two new pyrazolyl pyridine derivatives L1 and L2 connected by calixarene bridge were designed and synthesized by 4-phenyl phenol and 4-tert-butyl phenol.The structure of L1and L2 was ascertained by 1 H NMR,13 C NMR.The study showed that L1 could accelerate Suzuki cross-coupling reaction in solvent with V(DMF)∶V(水)=2∶1 at 80℃.

关 键 词：催化化学 吡唑基吡啶 SUZUKI偶联反应 杯芳烃 

分 类 号：O626.21[理学—有机化学] O643.36[理学—化学]