血小板平均容积对急性非ST段抬高型心肌梗死介入治疗患者长期预后的影响  

Influence of mean platelet volume on long-term outcomes among patients with acute non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention

作　　者：张琳[1] 孙志军[1] 于彤彤[1] 宋佳[1] 何东旭[1] 田春阳[1] 孙兆青[1] Lin Zhang;Zhi-jun Sun;Tong-tong Yu;Jia Song;Dong-xu He;Chun-yang Tian;Zhao-qing Sun(Department of Cardiovascular Medicine,Shengjing Hospital of China Medical University,Shenyang,Liaoning 110020,China)

机构地区：[1]中国医科大学附属盛京医院心血管内科,辽宁沈阳110020

出　　处：《中国现代医学杂志》2019年第4期53-57,共5页China Journal of Modern Medicine

基　　金：辽宁省科技厅科学技术计划项目(No:2011225020)

摘　　要：目的探讨血小板平均容积对急性非ST段抬高型心肌梗死(NSTEMI)介入治疗患者长期预后的影响。方法选取2010年1月—2014年10月在中国医科大学附属盛京医院确诊为NSTEMI且行经皮冠状动脉介入(PCI)治疗的885例患者。基于血小板平均容积(MPV)水平,将患者分为低MPV组756例(MPV<10.94 fl)和高MPV组129例(MPV≥10.94 fl)。通过单因素及多因素Cox回归分析,研究MPV对NSTEMI行PCI治疗患者预后的影响。结果平均随访30.9个月,与低MPV组比较,高MPV组全因死亡及心源性死亡率更高(P <0.05);多因素校正后Cox分析显示,高MPV是行PCI的NSTEMI患者全因死亡[H^R=1.390(95%CI:1.130,1.710),P=0.002]及心源性死亡[H^R=1.306(95%CI:1.027,1.662),P=0.030]事件的危险因素;Kaplan-Meier生存曲线显示,高MPV组不良心血管事件发生率更高,预后不佳(P<0.05)。结论 MPV是NSTEMI患者PCI术后不良预后的危险因素。Objective To investigate the influence of mean platelet volume on long-term outcomes among patients with acute non-ST-segment elevation myocardial infarction after percutaneous coronary intervention.Methods A total of 885 NSTEMI patients underwent PCI in our hospital from January 2010 to October 2014 were selected.According to the baseline MPV values,885 NSTEMI patients were divided into two groups:low MPV group(n=756 MPV<10.94 fl)and high MPV group(n=129 MPV≥10.94 fl).Univariate and multivariate Cox regressions were established to analyze influence of MPV on the prognosis of such patients.Results After 30.9-month follow-up time,compared with low MPV group,the rates of all-cause mortality and cardiac mortality in high MPV group were higher.Multivariate analysis showed high MPV was a risk factor of all-cause mortality[HR=1.390,(95%CI:1.130,1.710),P=0.002]and cardiac mortality[HR=1.306,(95%CI:1.027,1.662),P=0.030].The Kaplan-Meier survival curve showed high MPV group had the higher incidences of major adverse cardiac events.Conclusions MPV is an independent risk factor of poor prognosis after PCI for NSTEMI patients.

关 键 词：心肌梗死/心肌梗塞 冠状动脉疾病 血小板 预后 

分 类 号：R543.3[医药卫生—心血管疾病]