围手术期慢性心律失常使用尼非卡兰疗效观察  

Clinical observation of perioperative chronic arrhythmias using Nifekalant

作　　者：危佳[1,2] 刘艳波 WEI Jia;LIU Yanbo(The Poeple’s Hospital of China Three Gorges University and First Poeple’s Hospital of Yichang,Hubei Yichang 443000,China;Institute of Pharmaceutic Preparation,China Three Gorges University,Hubei Yichang 443000,China;Department of Pharmacy,Xiangyang No.1 People’s Hospital Affiliated of Hubei University of Medicine,Xiangyang 441000,China)

机构地区：[1]三峡大学人民医院.宜昌市第一人民医院,湖北宜昌443000 [2]三峡大学药物制剂研究所,湖北宜昌443000 [3]湖北医药学院附属襄阳市第一人民医院药学部,湖北襄阳441000

出　　处：《中国处方药》2019年第2期107-108,共2页Journal of China Prescription Drug

摘　　要：目的探讨围手术期使用尼非卡兰治疗慢性心律失常临床疗效,并研究适宜的治疗方案。方法随机选取心脏科病房围手术期心律失常患者96例作为研究对象,以随机数字法分为观察组和对照组,每组48例。观察组使用尼非卡兰,对照组使用胺碘酮、利多卡因等典型药物,用于治疗电复律无效的心律失常,统计其复律效果、平均起效时间以及不良反应发生情况,评价临床治疗效果并制定给药方案。结果临床统计分析显示,对电复律无效的观察组复律百分比为64.58%(31/48),对照组复律百分比为52.08%(25/48),差异有统计学意义(P <0.05);统计两组平均复律时间,观察组明显小于对照组,差异有统计学意义(P <0.05)。副作用平均发生率观察组6.25%(3/48),少于对照组16.67%(8/48),差异有统计学意义(P <0.05)。结论尼非卡兰复律成功率高于其他药物,复律时间快于胺碘酮和利多卡因,副作用发生率较低。Objective To investigate the clinical efficacy of Nifekalant in the treatment of chronic arrhythmia during perioperative period,and to study the appropriate treatment plan.Methods A total of 96 patients with perioperative arrhythmia in the cardiology ward of our hospital were randomly selected as the study subjects.The patients were divided into observation group and control group by random number method,48 cases in each group.Nifekalant was used in the observation group,and a typical drug such as amiodarone or lidocaine was used in the control group to treat arrhythmia in which cardioversion was ineffective.And the effects of cardioversion,mean time of onset,and adverse reactions were counted,evaluated the clinical treatment effect and formulate a dosing regimen.Results Clinical statistical analysis showed that the percentage of cardioversion in the observation group was 64.58%(31/48),and the percentage of cardioversion in the control group was 52.08%(25/48).The difference was statistically significant(P<0.05).The average cardioversion time of the two groups was statistically observed.The observation group(3 min)was smaller than the control group(22 min),and the difference was statistically significant(P<0.05).The average incidence of side effects was 8.33%(4/48)in the observation group and 16.67%(8/48)in the control group.The difference was statistically significant(P<0.05).Conclusion The success rate of Nifekalant's cardioversion was higher than other drugs.The cardioversion time was faster than Amiodarone and Lidocaine,and the incidence of side effects was lower.

关 键 词：围手术期 慢性心律失常 尼非卡兰 疗效观察 

分 类 号：R541.7[医药卫生—心血管疾病]