国内骨质疏松性骨折预测方法的研究进展  

Research on the Progress in the Prediction Method of Osteoporotic Fractures in China

作　　者：唐孝华 李峰 朱钧[3] TANG Xiaohua;LI Feng;ZHU Jun(Department of Orthopedics,Huaihua People’s Hospital Affiliated to the University of South China,Huaihua Hunan 418000,China;Department of Orthopedics,The First Affiliated Hospital of Hunan University of Medicine,Huaihua Hunan 418000,China;Department of Orthopedics,The First People’s Hospital in Huaihua City,Huaihua Hunan 418000,China)

机构地区：[1]南华大学附属怀化医院骨科,湖南怀化418000 [2]湖南医药学院附属第一医院骨科,湖南怀化418000 [3]怀化市第一人民医院骨科,湖南怀化418000

出　　处：《中国继续医学教育》2019年第6期99-101,共3页China Continuing Medical Education

基　　金：湖南省自然科学基金项目(2015JJ4037)

摘　　要：骨质疏松性骨折(osteoporosis fracture,OF)是骨质疏松症的严重并发症,愈后差,严重影响了患者的预期寿命、身心健康,增加家庭和社会的经济负担,早期对其进行预测极为重要。目前主要有以下几种预测骨质疏松性骨折的方法 :骨密度、FRAX检测工具、骨转换生化标志物、定量骨超声等。FRAX是一种应用临床危险因素来评估每一位个体发生骨质疏松性骨折绝对风险的工具,应用广泛。骨密度预测的骨质疏松性骨折风险是一个总体风险。骨转换生化标志物应用于骨折预测的研究结论尚存在争议。定量骨超声不能进行统一质控,临床应用受到限制。研究表明,FRAX工具能够预测个体10年内发生主要部位及髋部的骨质疏松性骨折的概率,比其它的方法更优越。Osteoporosis fracture (OF) is a serious complication of osteoporosis,which is not good after caring and seriously affects the life expectancy,physical and mental health of patients,and increases the economic burden of family and society.So early predictions are extremely important.At present,there are mainly the following methods of predicting osteoporotic fractures:bone density,FRAX detection tools,biochemical markers of bone turnover,and quantitative bone ultrasound.FRAX is a widely used tool for assessing the absolute risk of osteoporotic fractures in each individual using clinical risk factors.The risk of osteoporotic fracture predicted by bone density is an overall risk.The conclusions of biochemical markers of bone turnover applied to fracture prediction are still controversial.Quantitative bone ultrasound cannot be subjected to uniform quality control,and clinical application is limited.Studies have shown that the FRAX tool can predict the probability of an individual's major site and hip osteoporotic fracture within 10 years,which is superior to other methods.

关 键 词：骨质疏松症(OP) 骨质疏松性骨折(OF) FRAX 骨折预测方法 骨密度(BMD) 骨转换生化标志物 定量骨超声(QUS) 

分 类 号：R580[医药卫生—内分泌]