叶酸代谢基因多态性的研究进展  

Research Progress of Folate Metabolic Gene Polymorphism

作　　者：李静[1] 郑玲利[1] 蒋婷[1] 邵英 袁明勇[1] LI Jing;ZHENG Linli;JIANG Ting;SHAO Ying;YUAN Mingyong(Department of Pharmacy,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院药学部,成都610500

出　　处：《医药导报》2019年第2期230-234,共5页Herald of Medicine

摘　　要：该文总结分析大量文献、国内大型学术会议报告了解以叶酸代谢基因导向的个体化给药在药学服务中的发展现状及前景,确定个体化用药方案的制定思路。叶酸代谢相关基因亚甲基四氢叶酸还原酶(MTHFR) C677T和蛋氨酸合成酶还原酶(MTRR) A66G不但与多种疾病的发生相关,而且根据其多态性可以指导临床个体化给药,从而增加药效或减少不良反应。Through summarizing and analyzing a large number of documents and reports of large academic conferences in China,the current situation and the prospect of individualized drug delivery model were analyzed based on folate metabolic gene in pharmaceutical care.Folate metabolic genemethylenetetrahydrofolate reductase(MTHFR)C677T and methionine synthase reductase(MTRR)A66G were related with development of multiple diseases.Its polymorphism guidesindividualized drug administrationto increase the efficacy of drugs or decrease adverse effects.

关 键 词：叶酸 亚甲基四氢叶酸还原酶 蛋氨酸合成酶还原酶 基因多态性 

分 类 号：R977.2[医药卫生—药品]