肺炎支原体肺炎患儿血浆sB7-H1及细胞因子的表达与临床意义  

Expression and Clinical Significance of Plasma Soluble B7-H1 and Cytokines in Children with Mycoplasma Pneumoniae Pneumonia

作　　者：郭素玉 朱灿红[1] 张新星[1] 顾文婧[1] 季伟[1] 严永东[1] 杜培培 陈正荣[1] Guo Suyu;Zhu Canhong;Zhang Xinxing;Gu Wenjing;Ji Wei;Yan Yongdong;Du Peipei;Chen Zhengrong(Children's Hospital of Soochow University,Jiangsu Soochow 215003,China)

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003

出　　处：《儿科药学杂志》2019年第2期1-4,共4页Journal of Pediatric Pharmacy

基　　金：国家自然科学基金项目;编号81570016;苏州市"科教兴卫"青年科技项目;编号KJXW2016019;苏州市应用基础研究(医疗卫生)项目;编号SYSD2016101

摘　　要：目的:探讨肺炎支原体肺炎(MPP)患儿血浆中可溶性B7-H1(sB7-H1)的表达水平及其与各细胞因子的关系及临床意义。方法:选取2015年在苏州大学附属儿童医院呼吸科住院治疗的MPP患儿87例,并选取同期外科择期手术的31例患儿作为对照组。采用酶联免疫吸附试验(ELISA)分别检测MPP患儿血浆中sB7-H1、IFN-γ、IL-4、IL-17、IL-36α及GM-CSF的表达水平。结果:MPP组的sB7-H1水平为(1 045±356. 50) pg/m L,高于对照组的(294. 16±218. 33) pg/m L,且经治疗后sB7-H1水平下降(P<0. 01)。MPP患儿sB7-H1水平与IL-36α呈正相关,而与IFN-γ、IL-4、IL-17、GM-CSF无显著相关性。结论:sB7-H1在MPP患儿具有高表达,可能在过度免疫反应中起一定的作用。Objective:To probe into the expression level and clinical significance of plasma soluble B7-H1(sB7-H1)and its correlation with various cytokines in children with Mycoplasma pneumoniae pneumonia(MPP).Methods:Totally 87 children admitted into the pneumology department of Children's Hospital of Soochow University in 2015 were extracted as the MPP group,while 31 children with elective surgery in the same period were selected as the control group.The expression levels of sB7-H1,IFN-γ,IL-4,IL-17,IL-36αand GM-CSF in plasma of children with MPP were detected by enzyme-linked immunosorbent assay(ELISA).Results:The sB7-H1 level of MPP group was(1 045±356.50)pg/mL,higher than that of control group(294.16±218.33)pg/mL,and the sB7-H1 level decreased after treatment(P<0.001).The sB7-H1 level was positively correlated with IL-36αin children with MPP,yet not significantly correlated with IFN-γ,IL-4,IL-17 and GM-CSF.Conclusion:sB7-H1 has high expression in children with MPP and may play a role in excessive immune inflammation.

关 键 词：肺炎支原体肺炎 sB7-H1 细胞因子 过度免疫 儿童 

分 类 号：R725.6[医药卫生—儿科]