伊红荷移光度法测定盐酸地尔硫卓的含量  

Spectrophotometric Determination of Diltiazem Hydrochloride by Its Charge-Transfer Reaction With Eosin Y

作　　者：王晓玲[1] 张萍[1] WANG Xiao-ling;ZHANG Ping(School of Chemistry & Chemical Engineering,Xianyang Normal University,Shaanxi Xianyang 712000,China)

机构地区：[1]咸阳师范学院化学与化工学院,陕西咸阳712000

出　　处：《当代化工》2019年第1期218-220,共3页Contemporary Chemical Industry

摘　　要：实验研究了在p H=3.6的邻苯二甲酸氢钾-HCl缓冲液中,盐酸地尔硫卓与伊红可形成稳定的电荷转移络合物,据此建立了盐酸地尔硫卓荷移光度分析的新方法。络合物最大吸收波长为550 nm,表观摩尔吸光系数为4.61×104 L·mol-1·cm-1,其线性方程为Y=0.488 3X+0.024 5,相关系数,R=0.999 8,盐酸地尔硫卓的量在1.5～7.5 mg·L-1质量浓度范围内符合朗伯比尔定律,该法选择性和重现性好,灵敏度较高,可用于快速检测药品中盐酸地尔硫卓的含量。A novel spectrophotometric method for the determination of diltiazem hydrochloride was established based on the charge transfer reaction between diltiazem hydrochloride and eosin Y in pH=3.6 potassium hydyogen phthalate-HCl. The results showed that the apparent molar absorptivity of the color complex was 4.61×104 L·mol-1·cm-1 at 550 nm. The linear regression equation was Y=0.488 3X+0.024 5, the correlation coefficient was 0.999 8, the adsorption conformed to Lambert-Beer law in the range of 1.5~7.5 mg·L-1.The method is simple, rapid, high sensitive and suitable for determination of diltiazem hydrochioride content in medicine.

关 键 词：盐酸地尔硫卓 伊红 荷移光度法 

分 类 号：O657.32[理学—分析化学]