特立氟胺的合成工艺改进  

Improved Synthesis of Teriflunomide

作　　者：冯一峻 何子聪 王晶[3] 王德才[3] Feng Yijun;He Zizong;Wang Jing;Wang Decai(Nanjing No.9 Middle School, Jiangsu Nanjing 210018;Nanjing Tianjiabing Senior High School, Jiangsu Nanjing 210037;Nanjing Tech University, Jiangsu Nanjing 211800)

机构地区：[1]南京市第九中学,江苏南京210018 [2]南京田家炳高级中学,江苏南京210037 [3]南京工业大学,江苏南京211800

出　　处：《化工时刊》2019年第1期23-24,54,共3页Chemical Industry Times

摘　　要：以氰乙酸为原料,通过氯化、酰胺化、C-酰化反应等合成特立氟胺,总收率为81. 7%,产物经NMR和HRMS等谱图确证。该工艺原料易得,条件温和,产率较高,适合工业化生产。Teriflunomide was synthesized by a serial reactions of chlorination,amidationand C-acylationfrom cyanoacetic acid.The overall yield was about 81.7%,and the structure of the product was confirmed by NMR and HRMS.The process route is easy to obtain raw materials with mild conditions and high yield.Thus it is suitable for industrial production.

关 键 词：氰乙酸 合成 特立氟胺 

分 类 号：TQ463[化学工程—制药化工]