2型猪圆环病毒研究进展  

Progress in the Study of Porcine Circovirus 2

作　　者：符贻武 陈豪泽 党佳慧 李天一 李思琪 马明爽 刘东旭[1,2] FU Yi-wu;CHEN Hao-ze;Dang Jia-hui;Li Tian-yi;Li Si-qi;MA Ming-shuang;LIU Dong-xu(Jilin Agricultural Science and Technology University,Jilin,Jilin,132101,China;Key Lab of Preventive Veterinary Medicine in Jilin Province,Jilin,Jilin,132101,China)

机构地区：[1]吉林农业科技学院,吉林吉林市132101 [2]预防兽医学吉林省重点实验室,吉林吉林市132101

出　　处：《吉林畜牧兽医》2019年第1期10-12,共3页Jilin Animal Husbandry and Veterinary Medicine

基　　金：吉林省大学生科技创新创业项目(吉农院合合字[2018]第080号);吉林省科技发展计划项目(20150623004TC)

摘　　要：猪圆环病毒2型(Porcine circovirus type 2,PCV2)是一种基因组较小,但有较高进化速率的DNA病毒,其是影响养猪业经济发展的重要病原体。到目前为止,PCV2具有5种基因型-PCV2a到PCV2e,但对PCV2流行株的基因序列的检测发现,PCV2的基因型仍在持续的发展。自2012年以来,PCV2d基因型的圆环病毒在北美取代了以前主导的PCV2b基因型感染,同时在中国和韩国也有了类似的趋势。圆环病毒的新兴基因型,其毒力存在增强的可能性,基于PCV2a基因型制备的疫苗,是否对PCV2d基因型圆环病毒的感染具有保护作用,已引起各国学者的重视。本文通过对PCV2的生物学特性、抗体变异情况以及其基因进化情况进行综合的分析总结,从而为PCV2疫苗的开发与研制奠定理论基础。Porcine circovirus type 2(PCV2)is an economically important swine pathogen and,although small,it has the highest evolution rate among DNA viruses.Since the discovery of PCV2 in the late 1990s,this minimalistic virus with a 1.7 kb single-stranded DNA genome and two indiapensable genes has become one of the most important porcine pat hogens,and presently is subjected to the highest volume of prophylactic intervention in the form of vaccines in global swine production.PCV2 can currently be divided into five different genotypes,PCV2a through PCV2e.It is well documented that PCV2 continues to evolve,which is reflected by changes in the prevalen ce of genotypes.Since 2012,the PCV2d genotype has essentially replaced the previously predominant PCV2b genotype in North America and similar trends are also documented in other geographic regions such as China and South Korea.The potential increase in virulence of the emergent PCV2 genotype and the efficacy of the current vaccines derived from PCV2a genotype against the PCV2d genotype viruses has received considerable attention.This review attempts to synthesize the understanding of PCV2 biology,experimental studies on the antigenic variability,and molecular epidemiological analysis of the evolution of PCV2 genotypes.

关 键 词：PCV2 流行病学 猪 疫苗 

分 类 号：S858.28[农业科学—临床兽医学]