溶血磷脂酸(LPA)在老年糖尿病患者管理中的应用研究  

Application of lysophosphatidic acid(LPA) in the management of elderly diabetic patients

作　　者：李志坚 黄焕峰 LI Zhijian;HUANG Huanfeng(The Administrative Office of Guangzhou Aotou Town Center Health Center Of Conghua District,Guangzhou 510940,China;The Department of CardiovascularMedicine,The Second People's Hospital of Guangzhou Huadu District,Guangzhou 510850,China)

机构地区：[1]广州市从化区鳌头镇中心卫生院行政办公室,广州510940 [2]广州市花都区第二人民医院心血管内科,广州510850

出　　处：《广州医药》2019年第1期21-23,共3页Guangzhou Medical Journal

摘　　要：目的探索使用血浆中溶血磷脂酸LPA作为老年糖尿病患者发生缺血性心脑血管病早期预警指标。方法在公共卫生项目开展的基础上,将老年糖尿病患者随机分为观察组和对照组。对照组实施糖尿病规范管理,观察组在对照组的基础上进行血浆LPA的水平定期检测,对LPA明显升高者,予降脂、抗纤溶、抗血小板凝集等干预措施,比较两组间缺血性心脑血管病发生率和病情严重程度。结果观察组缺血性脑血管发病率高于对照组,差异有统计学意义(P<0.05)。中、重型缺血性脑血管病患者的血浆LPA高于轻型组(P<0.05),且重型组高于中型组(P<0.05)结论血浆LPA值可作为老年糖尿病患者发生缺血性心脑血管病的预警因子,值得在基层老年糖尿病患者规范化管理中常规应用。Objective To explore the early warning index of ischemic cardiocerebrovascular disease in elderly diabetic patients with plasma LPA.Methods On the basis of public health project,elderly diabetic patients were randomly divided into observation group and control group.Control group adopted diabetes management implementation,while observation group adopted periodic testing of the levels of plasma LPA on the basis of the control group,implementing fall fat,resisting fibrinolytic,antiplatelet aggregation and other interventions if LPA significantly increased.We compared the ischemic cardio-cerebrovascular disease incidence and disease severity between the two groups.Results The incidence of cerebral ischemia in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Medium and heavy plasma LPA is higher than the light of ischemic cerebrovascular disease group(P<0.05),and heavy above medium group(P<0.05)Conclusion The plasma LPA values can be used as early warning factor in elderly patients with diabetes occuring ischemic cardio-cerebrovascular disease and promote its application.

关 键 词：老年人 糖尿病 血浆溶血磷脂酸(LPA) 缺血性心脑血管疾病 

分 类 号：R587.1[医药卫生—内分泌]