腔隙性脑梗死与认知功能及情感障碍的相关性研究  

Correlation between lacunar infarction,cognitive function and affective disorder

作　　者：夏瑞雪[1] 张俊玲[1] 李艳华[1] 张丽冉[1] 洪震[1] 戴建宁[1] Xia Ruixue;Zhang Junling;Li Yanhua;Zhang Liran;Hong Zhen;Dai Jianning(Second Department of Neurology,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市中心医院神经内二科,河北沧州061000

出　　处：《海军医学杂志》2019年第1期44-47,共4页Journal of Navy Medicine

基　　金：沧州市科学技术研究与发展指导计划(172302135)

摘　　要：目的探讨腔隙性脑梗死与认知功能及情感障碍的相关性。方法将2017年1月至2018年1月沧州市中心医院收治的35例腔隙性脑梗死患者作为研究组,30例非脑血管疾病患者为对照组。采用简易智力状态检查量表(MMSE量表)评估2组患者的认知功能,汉密尔顿抑郁量表(HAMD量表)、汉密尔顿焦虑量表(HAMA量表)评估2组患者的情感障碍情况,并比较2组患者上述评分差异及认知障碍、情感障碍情况发生情况;同时采用美国国立卫生研究院卒中量表(NIHSS)对研究组患者病情严重程度进行评估,并分析研究组患者病情严重程度、梗死数目及体积与认知功能及情感障碍的相关性。结果研究组情感障碍与认知障碍发生率均高于对照组,差异有统计学意义(P<0.05);研究组MMSE评分[(24.20±4.57)分]比对照组低[(26.83±4.96)分],HAMD评分[(7.09±5.26)分]、HAMA评分[(9.16±5.13)分]比对照组高[(4.39±4.10)分、(6.13±4.86)分],差异有统计学意义(P<0.05)。研究组患者NIHSS评分与HAMD评分、HAMA评分呈显著正相关,与MMSE评分呈负相关差异均有统计学意义,(P<0. 05);患者梗死体积与MMSE评分呈负相关,差异均有统计学意义(P<0. 05),但与HAMD评分及HAMA评分无显著相关性(P>0.05)。患者梗死数量与MMSE评分呈负相关,与HAMD评分与HAMA评分呈正相关差异均有统计学意义,(P<0.05);颞叶、顶叶及额叶梗死数目与MMSE评分呈负相关性,额叶及枕叶梗死数目与患者HAMD评分呈正相关性差异均有统计学意义,(P<0.05)。结论腔隙性脑梗死患者病情严重程度、梗死体积及数目与患者认知功能/情感状况密切相关。Objective To study the correlation between lacunar infarction,cognitive function and affective disorders.Methods Thirty-five patients with lacunar infarction were designated as the study group,and 30 patients with non-cerebrovascular disease were assigned as the control group.The Mini-mental state exam(MMSE)scale was used to evaluate the cognitive function of the two groups.The Hamilton depression(HAMD)scale and the Hamilton anxiety(HAMA)scale were used to evaluate the affective disorder of the two groups.The differences in scores and the rates of cognitive and affective disorders were compared between the two groups.At the same time,the severity of the disorder,the number and size of infarcts in the study group were evaluated by using the National Institute of Health Stroke Score(NIHSS),and correlation between the severity of the disorder,the number and size of infarcts,cognitive function and affective disorder was analyzed statistically.Results The rates of affective disorder and cognitive impairment in the study group were all higher than those in the control group(P<0.05).The MMSE scores [(24.20± 4.57)scores] of the study group were lower than those of the control group[(26.83± 4.96)scores],the HAMD [(7.09± 5.26)scores] and HAMA scores[(9.16±5.13)scores]of the study group were higher than those of the control group [(4.39±4.10)scores,(6.13±4.86)scores],with statistical significance(P<0.05).The NIHSS scores of the study group were positively correlated with the HAMD and HAMA scores(P<0.05),but were negatively correlated with the MMSE scores(P<0.05).The infarct size was negatively correlated with the MMSE scores(P<0.05),but there was no significant correlation,when it was compared with the HAMD and HAMA scores(P<0.05).The number of infarcts was negatively correlated with MMSE scores(P<0.05),and it was positively correlated with the HAMD and HAMA scores(P<0.05).The number of infarcts in the temporal,parietal and frontal lobes was negatively correlated with the MMSE scores(P<0.05),but the number of infarcts

关 键 词：腔隙性脑梗死 认知功能 情感障碍 相关性 

分 类 号：R3951[哲学宗教—心理学]