轴突诱导因子4D和Ki67在胰腺癌中的表达及其与临床病理特征的关系  

Expression of Sema4D and Ki67 in pancreatic carcinoma and its relationship with clinicopathological features

作　　者：贾如江[1] 侯丽艳[1] 尹清臣[1] JIA Rujiang;HOU Liyan;YIN Qingchen(Handan Central Hospital,Handan,Hebei 056102,China)

机构地区：[1]邯郸市中心医院,河北邯郸056102

出　　处：《临床肝胆病杂志》2018年第1期160-163,共4页Journal of Clinical Hepatology

摘　　要：目的探讨轴突诱导因子4D(Sema4D)和Ki67在胰腺癌中的表达与临床病理特征的关系。方法采用免疫组化(SP)法检测2013年1月-2016年12月邯郸市中心医院收集的40例胰腺癌组织及10例癌旁组织中Sema4D和Ki67蛋白的表达,并分析其与临床病理学特征的关系。2组间计数资料的比较采用χ~2检验,相关性分析采用Spearman秩相关法。结果 Sema4D和Ki67在胰腺癌组织中的阳性表达率分别为47.5%(19/40)和45.0%(18/40),高于二者在癌旁组织中的表达,差异均有统计学意义(χ~2值分别为10.040、10.000,P值分别为0.020、0.022)。Sema4D和Ki67的异常表达在不同肿瘤分期、淋巴结是否转移的患者中存在显著差异(χ~2值分别为6.352、4.912、12.031、6.465,P值分别为0.013、0.028、0.001、0.025)。Sema4D和Ki67的表达呈正相关(r=0.347,P=0.028)。结论在胰腺癌组织中Sema4D和Ki67较其在胰腺癌癌旁组织中的表达明显升高,二者具有协同作用,与胰腺癌肿瘤分期、淋巴结转移有关。Objective To investigate the expression of Sema4D and Ki67 in pancreatic carcinoma and its relationship with clinicopathological features.Methods The expression of Sema4D and Ki67 in 40 pancreatic carcinoma tissues and 10 adjacent tissues was measured by immunohistochemistry,and its relationship with the clinicopathological features of pancreatic carcinoma was analyzed.Comparison of categorical data between two groups was made by chi-square test.Spearman′s rank correlation analysis was used to identify the correlation between these variables.Results Sema4D and Ki67 were detected in 19(47.5%)and 18(45.0%),respectively,of the 40 pancreatic carcinoma tissues,with significantly higher positive rates than the adjacent tissues(χ^2=10.040 and 10.000,P=0.020 and 0.022).The abnormal expression of Sema4D and Ki67 differed significantly between patients with different tumor stages and between patients with and without lymph node metastasis(χ^2=6.352,4.912,12.031,and 6.465,P=0.013,0.028,0.001,and 0.025).Sema4D expression was positively correlated with Ki67 expression(r=0.347,P=0.028).Conclusion The expression of Sema4D and Ki67 is elevated in pancreatic carcinoma compared with the adjacent tissue.Their expression is positively correlated with each other and is associated with tumor staging and lymph node metastasis.

关 键 词：胰腺肿瘤 KI-67抗原 信号素类 病理状态 体征和症状 

分 类 号：R735.9[医药卫生—肿瘤]