管式反应器连续化合成3,5,6-三氯吡啶-2-醇钠工艺研究  

Study of Continuous Preparation of 3,5,6-Trichloropyridin-2-ol Sodium with Tetrachloropyridine Using a Tubular Reactor

作　　者：周爱民 王佳 汪姣 濮梦华 ZHOU Ai-min;WANG Jia;WANG Jiao;PU Meng-hua(Anhui Costar Biochemical Co.Ltd.,Anhui Miscellaneous Ring Key Laboratory,Maanshan 243100,China)

机构地区：[1]安徽国星生物化学有限公司安徽省杂环化学实验室,安徽马鞍山243100

出　　处：《安徽化工》2019年第1期68-70,共3页Anhui Chemical Industry

摘　　要：以2,3,5,6-四氯吡啶为原料,采用管式反应器在水中与氢氧化钠水解合成3,5,6-三氯吡啶-2-醇钠,并对工艺进行了优化,四氯吡啶与2.2倍氢氧化钠在4倍溶剂水用量下,停留时间8 min,在140℃下连续反应,四氯吡啶转化率100%,产物收率98.0%。This research is carried out on the preparation of 3,5,6-trichloropyridin-2-ol sodium with tetrachloropyridine,sodium hydroxide and water,by adopting a tubular reactor,and the process is optimized.The conversion of tetrachloropyridine was 100%and the yield of 3,5,6-trichloropyridin-2-ol sodium was 98.0%when the reaction temperature is 140℃,and the reaction mixture is allowed to remain in the reaction zone for a period of 8 minutes,use 2.2 mol sodium hydroxide and 4 times the mass of water,based on tetrachloropyridine.

关 键 词：四氯吡啶 3 5 6-三氯吡啶-2-醇钠 毒死蜱 连续化 

分 类 号：F767.2[经济管理—产业经济]