大鼠肝癌模型建立的研究进展  

Research progress in establishing rat liver cancer models

作　　者：韦武 郭红星 WEI Wu;GUO Hongxing(Tianjin Key Laboratory of Hemoperfusional Technology Enterprise, Tianjin Zibo High-Tech Co.Ltd., Tianjin 300170, China;Technology Research Center of Artificial Cell Engineering, Ministry of Health, Tianjin Institute of Hepatobiliary Diseases,Tianjin Third Central Hospital, Tianjin 300170)

机构地区：[1]天津市血液灌流技术企业重点实验室天津市紫波高科技有限公司,天津300170 [2]卫生部人工细胞工程技术研究中心天津市肝胆疾病研究所天津市第三中心医院,天津300170

出　　处：《中国实验动物学报》2019年第1期119-123,共5页Acta Laboratorium Animalis Scientia Sinica

基　　金：天津市卫生局攻关项目(2013-GG-05);天津市科技支撑重点研究计划项目(15ZCZDGX00280)~~

摘　　要：肝癌动物模型是研究肝癌的重要依据,其在揭示肿瘤发病机制、评估治疗方法中的角色不可或缺。近年来,研究人员借助不同类型的动物模型不断获得有关肝癌及其治疗预后的丰富数据。本文通过总结常用的诱发性和移植性大鼠肝癌的建模方式及应用,以呈现近年来在构建大鼠肝癌模型实践中的进展。Animal models are necessary for studying liver cancer as they play a vital role in exploring tumor pathogenesis and evaluating therapeutic methods. In recent years, abundant data from liver cancer studies and treatment prognoses have been obtained via various animal models. Here, we summarize the commonly used rat liver cancer models, which are mainly constructed by induction or transplantation, and discuss the progress made in establishing rat liver cancer models.

关 键 词：大鼠 肝癌 动物模型 

分 类 号：Q95-33[生物学—动物学]