ADC值在评估代偿期乙肝肝硬化相关肾功能改变的应用价值  

Application of ADC Value in the Evaluation of Renal Function after Chronic Hepatitis B Compensated Cirrhosis

作　　者：李锋 王晓野 林锦仕 LI Feng;WANG Xiao-ye;LIN Jin-shi(Department of Imaging Diagnose,Zhuhai Integrated Chinese and Western Medicine Hospital,Zhuhai 519000,Guangdong Province,China)

机构地区：[1]广东省珠海市中西医结合医院影像科,广东珠海519000

出　　处：《中国CT和MRI杂志》2018年第12期100-102,共3页Chinese Journal of CT and MRI

基　　金：广东省珠海市科技和工业信息化局资助项目;编号:2015A0011

摘　　要：目的本研究旨在通过对核磁共振DWI的研究,分析ADC值在评估代偿期乙肝肝硬化相关肾功能改变的应用价值。方法 2015年7月至2017年1月,在我院就诊的46例乙肝代偿期肝硬化患者纳入研究组,搜集40例健康正常志愿者作为对照组。入组均接受1.5T磁共振扫描,扩张加权成像b值选择600s/mm2,后处理工作站测量肾脏ADC值。采用配对样本t检验比较两组左右肾脏ADC值的差异。两个独立样本t检验比较两组之间肾脏ADC值的差异。采用ROC曲线分析指标的诊断效能。结果研究组内、对照组内双侧肾脏平均ADC值差异无统计学意义(P>0.05)。研究组和对照组双肾平均ADC值差异有统计学意义(P<0.01)。ROC曲线分析显示,ADC值1.93×10-3mm2/s作为临界值,敏感度为80.4%,特异度为76.9%,ROC曲线下的面积为0.72。结论作为无创性功能成像技术,ADC值可以作为评估和随访代偿期乙肝肝硬化相关肾功能的有效方法。Objective The aim of study was to investigate Diffusion-weighted imaging(DWI),and to analyze the value of ADC value in the evaluation of renal function after chronic hepatitis B compensated cirrhosis.Methods From July 2015 to January 2017,46patients with chronic hepatitis B compensated cirrhosis in the hospital were enrolled in this study.And 40 healthy outpatients were enrolled as control group.In both experimental and control group,1.5T magnetic resonance imaging was performed,and the expansionweighted imaging b value was chosen to be 600s/mm^2.The post-processing work station measured the each group renal of ADC value.The paired-samples t test was conducted to analyze the difference of ADC value between the right and left renal in each group.The difference of ADC value between experimental and control group was analyzed by independent t test.The ROC curve was used to analyze the distinguishing value of ADC value among the groups.Results No statistical differences were found in ADC value between the right and left renal in each group(P>0.05).There was a significant difference of ADC value between experimental and control group(P<0.01).ROC analysis showed that the area under the ROC curve(AUC)for ADC value was 0.72 and that the optimal cut off value of ADC for differentiating experimental and control group was 1.93×10^-3mm^2/s(sensitivity,80.4%,specificity,76.9%).Conclusion The noninvasive and noncontrast agent needed characteristic might make ADC value an effective method for detecting and monitoring kidney function in patients with chronic hepatitis B compensated cirrhosis.

关 键 词：慢性乙型肝炎 肝硬化 肾功能 弥散加权成像 表观弥散系数 

分 类 号：R512.62[医药卫生—内科学] R575.1[医药卫生—临床医学]