清心泻脾法内外合治对心脾积热型小儿手足口病患儿心肌酶及白细胞分类的影响  

Effect of Qingxin Xiepi method on myocardial enzymes and leucocyte classification in children with hand-foot-mouth disease(heart-spleen-heat type)

作　　者：龙华婧[1] 邱芳华[2] 范文萃[3] 李秋明[1] 刘道利[1] 徐雯[3] LONG Huajing;QIU Fanghua;FAN Wencui;LI Qiuming;LIU Daoli;XU Wen(Department of Clinical Laboratory,Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130,China)

机构地区：[1]广州市中医医院检验科,广州510130 [2]广州市中医医院院感科,广州510130 [3]广州市中医医院儿科,广州510130

出　　处：《中国中西医结合儿科学》2019年第1期15-18,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：广东省中医药局科研项目(20181200);广州市医药卫生科技项目(20171A010252)

摘　　要：目的观察清心泻脾法内外合治心脾积热型小儿手足口病对心肌酶及白细胞分类的影响。方法选择2016年5月至2017年11月广州市中医医院收治的手足口病患儿30例为研究对象,为观察组;同期选择健康体检儿童60例为对照组。分别检测观察组治疗前后以及对照组的心肌酶、白细胞分类。结果 (1)治疗前观察组乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)、白细胞计数、中性粒细胞绝对值、中性粒细胞百分数、中性粒细胞与淋巴细胞比值(N/L)和单核细胞绝对值高于对照组,肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)、淋巴细胞百分数低于对照组,差异有统计学意义(P<0.05)。(2)治疗后观察组LDH、α-HBDH、白细胞计数、中性粒细胞绝对值、中性粒细胞百分数、N/L值、单核细胞绝对值和单核细胞百分数水平显著低于治疗前,淋巴细胞绝对值和淋巴细胞百分数水平显著高于治疗前,差异有统计学意义(P<0.05)。(3)观察组经治疗后发热、口腔疱疹、手足部疱疹临床症状比治疗前有明显改善,差异有统计学意义(P<0.05)。结论清心泻脾法治疗心脾积热型手足口患儿的心肌酶及白细胞分类有较大改善,为该组方疗效提供理论依据。Objective To observe the Effect of Qingxin Xiepi method on myocardial enzymes and leucocyte classification in children with hand-foot-mouth disease(heart-spleen-heat type).Methods Thirty children with hand,foot and mouth disease admitted to Guangzhou Hospital of TCM from May 2016 to November 2017 were selected as the observation group.At the same time,60 healthy children were selected as the control group.Myocardial enzymes and leucocytes were detected before and after treatment in the observation group and in the control group.Results(1)LDH,α-HBDH,white blood cell count,neutrophil absolute value,neutrophil percentage,neutrophil to lymphocyte ratio(N/L)and monocyte absolute value in the observation group before treatment were higher than those in the control group,while CK,CK-MB and lymphocyte percentage were lower(P<0.05).(2)After treatment,the levels of LDH,α-HBDH,white blood cell count,absolute value of neutrophils,percentage of neutrophils,ratio of neutrophils to lymphocytes(N/L),absolute value of monocytes and percentage of monocytes in the observation group were significantly lower than those before treatment,while the absolute value of lymphocytes and percentage of lymphocytes were significantly higher(P<0.05).(3)The clinical symptoms of fever,oral herpes and hand-foot herpes in the observation group were significantly improved after treatment compared with those before treatment(P<0.05).Conclusion Myocardial enzymes and leukocyte classification are improved significantly by using the Qingxin Xiepi method in children with hand-foot-mouth disease(heart-spleen-heat type).It provides a theoretical basis for the efficacy of the prescription.

关 键 词：手足口病 清心泻脾法 加减导赤散 心肌酶 白细胞分类 儿童 

分 类 号：R272[医药卫生—中医儿科学]