缺血后处理与糖尿病心肌的研究进展  

Progress in Research on Ischemic Postconditioning and Diabetic Myocardium

作　　者：祝红丽 王海英[2] ZHU Hongli;WANG Haiying(School of Anesthesiology,Zunyi Medical University,Zunyi 563000,China;Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医学院麻醉医学院,贵州遵义563000 [2]遵义医学院附属医院麻醉科,贵州遵义563000

出　　处：《医学综述》2019年第3期510-514,共5页Medical Recapitulate

基　　金：国家自然科学基金(81660050)

摘　　要：缺血性心脏病是导致患者死亡的主要原因,缺血部位的血流再通至关重要,但随血流再通发生的心肌缺血再灌注损伤会严重影响患者预后,糖尿病患者较非糖尿病患者发生心肌缺血再灌注损伤的病死率升高。目前认为,糖尿病可弱化缺血后处理(IPO)的心肌保护作用,研究高血糖状态对心肌缺血再灌注损伤的影响、IPO心肌保护效应弱化的机制以及恢复IPO对糖尿病心肌保护作用的措施,对降低糖尿病患者病死率具有重要的临床意义和社会价值。Ischemic heart disease is the leading cause of death in patients,and recanalization of blood flow is essential,but myocardial ischemia reperfusion injury occurs with recanalization of blood flow,which severely affects the prognosis of the patient.The mortality of the diabetic patients after myocardial ischemia reperfusion injury is increased compared with the non-diabetic patients.It has been found that diabetes can weaken the myocardial protective effect of ischemic postconditioning(IPO).Therefore,studies on the effect of hyperglycemia on myocardial ischemia reperfusion injury,the mechanism of weakening the myocardial protective effect of IPO,and the recovery measures of myocardial protection by IPO have great clinical and social value for reducing the mortality of diabetic patients.

关 键 词：糖尿病 心肌缺血再灌注损伤 缺血后处理 心肌保护 

分 类 号：R541.9[医药卫生—心血管疾病] R587.1[医药卫生—内科学]