^(31)P(n,γ)^(32)P核反应制备高纯度磷[^(32)P]酸钠溶液  

Preparation of Sodium Phosphate [^(32)P]Solution via ^(31)P(n,γ)^(32)P

作　　者：孙志中[1,2] 陈云明 罗宁[1,2] 李兵 张劲松[1,2] 梁帮宏 胡银[1,2] 郭翔博 SUN Zhizhong;CHEN Yunming;LUO Ning;LI Bing;ZHANG Jinsong;LIANG Banghong;HU Yin;GUO Xiangbo(Nuclear Power Institute of China, Chengdu 610005, China;Sichuan Engineering Research Center for Raidoactive Isotope, Chengdu 610005, China)

机构地区：[1]中国核动力研究设计院,四川成都610005 [2]四川省放射性同位素工程技术研究中心,四川成都610005

出　　处：《同位素》2019年第1期1-6,I0001,共7页Journal of Isotopes

基　　金：中国核动力研究设计院核技术应用基金(JJXM-HJSY-14-01-03)

摘　　要：本研究以纯度为99.999%的赤鳞为靶料,通过^(31) P(n,γ)^(32) P核反应,在高通量工程试验堆(HFETR)内,热中子注量率为1.1×10^(14) n·cm^(-2)·s^(-1)时辐照28d。将辐照后的靶料用硝酸溶解、过氧化氢氧化、碳酸钠中和等化学处理,获得pH为7.0、放射性核纯度为99.999%、放化纯度为98.7%、放射性浓度为2.43×109 Bq·mL-1的有载体磷[^(32)P]酸钠溶液,其中磷含量为6.13mg·mL-1,满足2015年版《中国药典》对磷[^(32)P]酸钠口服溶液的技术指标要求。Phosphorus-32 is an attractive and widely used radionuclide for a variety of therapeutic applications owing to its favorable nuclear characteristics. 99.999% or above of the nuclear purity of sodium phosphate [ 32 P] oral solution must be achieved in 2015 P.R.C pharmacopoeia. In this manuscript, the process to prepare the sodium phosphate [ 32 P] solution was studied through the nuclear reaction 31 P (n,γ) 32 P on the high flux engineering test reactor (HFETR). 300 mg of red phosphorus at a thermal neutron flux of 1.1×10 ^14 n·cm ^-2 ·s ^-1 was irradiated for a period of 28 days, and after the sequential treatments of being dissolved in nitric acid, oxidized by hydroperoxide, and neutralized by sodium carbonate solution, a colorless and clear sodium phosphate [ 32 P] solution was obtained at pH 7. The solution was characterized by a nuclear purity being 99.999 9%, specific radioactivity being 2.43×10 ^9 Bq/mL, and phosphorus content being 6.13 mg/mL. The sodium phosphate [ 32 P ] solution fully meets the requirement of 2015 P.R.C pharmacopoeia and can be used as material to produce sodium [ 32 P] phosphate oral solution.

关 键 词：^31P(n γ)^32P 磷[^32P]酸钠 制备 

分 类 号：TL921.3[核科学技术—核燃料循环与材料]