利用HFETR制备高比活度锶-89溶液  

Preparation of High Specific Activity Strontium-89 Solution in High Flux Engineering Test Reactor

作　　者：罗宁[1,2] 曾俊杰 陈云明[1,2] 孙志中 张劲松[1,2] 梁帮宏 胡银[1,2] 李兵 钟军[1] 王小兵 LUO Ning;ZENG Junjie;CHEN Yunming;SUN Zhizhong;ZHANG Jinsong;LIANG Banghong(Nuclear Power Institute of China, Chengdu 610005, China;Sichuan Engineering Research Center for Raidoactive Isotope, Chengdu 610005, China)

机构地区：[1]中国核动力研究设计院,成都610005 [2]四川省放射性同位素工程技术研究中心,成都610005

出　　处：《同位素》2019年第1期7-12,I0001,共7页Journal of Isotopes

基　　金：中国核动力研究设计院核技术应用基金(JJXM-HJSY-14-01-01)

摘　　要：通过高通量工程实验堆(HFETR),利用核反应^(88)Sr(n,γ)^(89)Sr制备高比活度^(89 )SrCl_2溶液,用于骨转移癌的治疗。以高纯富集^(88)SrCO_3为靶料,在热中子注量率约2×10^(14 )n·cm^(-2)·s^(-1)条件下辐照56d,经溶解、过滤,制得无色澄清的^(89 )SrCl_2溶液,^(89 )Sr比活度7.77×10~9～1.08×10^(10 )Bq·g^(-1),活度浓度3.59×10~8～1.21×10^(9 )Bq·mL^(-1),γ杂质含量0.11%～0.14%,铝含量小于2μg·mL^(-1)(活度浓度换算为7.4×10^(7 )Bq·mL^(-1)时),明显优于《中国药典》指标。^(89)SrCl_2溶液经检验,满足行业要求,可用作生产^(89)SrCl_2注射液的原料。本研究完成单次7.4×10^(10 )Bq级高纯度和高比活度^(89)Sr制备装置研发,对医用同位素产品国产化具有重要意义。89 SrCl 2 is an important radioactive drug for the bone metastasis. It is included in the new pharmacopoeia in 2015 and has a promising future in the market. Depending on the high flux engineering test reactor(HFETR), the process of preparation of high specific activity 89 SrCl 2 solution by nuclear reaction 88 Sr(n,γ) 89 Sr was studied. High purity enriched 88 SrCO 3 was used as target material and irradiated for 56 days under the condition of thermal neutron fluence rate about 2×10 ^14 n·cm^-2 ·s^-1 . After dissolution and filtration, the colorless 89 SrCl 2 solution was obtained. The specific activity of 89 SrCl 2 solution was 7.77×10^ 9-1.08×10^ 10 Bq·g -1 , the activity concentration was 3.59× 10 ^8-1.21×10 ^9 Bq·mL -1 , the gamma impurity content was 0.11%-0.14%, the Al impurity content was much lower than 2 μg·mL^-1 (activity concentration 7.4× 10 ^7 Bq· mL^-1 ). 89 SrCl 2 solution had been tested to meet the requirements of the industry and could be used as raw material for the production of injection. The development of single 7.4×10 ^10 Bq level preparation device of high purity and high specific activity of 89 Sr had been finished. This research is important for localization of isotope products.

关 键 词：氯化锶[89Sr]溶液 堆照制备 医用同位素 高通量工程实验堆 

分 类 号：TL921.3[核科学技术—核燃料循环与材料]