正交试验优化逆萎康的水提工艺  

Optimization of Water Extraction Process of Niweikang by Orthogonal Test

作　　者：曹淑君 王辉明[2] 刘洪玲[2] 张翠萍[2] 凌勇[2] 孙向红[1,2] CAO Shujun;WANG Huiming;LIU Hongling;ZHANG Cuiping;LING Yong;SUN Xianghong(College of Pharmacy,Qingdao University,Qingdao,Shandong,China 266021;The Affiliated Hospital of Qingdao University,Qingdao,Shandong,China 266555)

机构地区：[1]青岛大学药学院,山东青岛266021 [2]青岛大学附属医院,山东青岛266555

出　　处：《中国药业》2019年第5期21-24,共4页China Pharmaceuticals

基　　金：山东省自然科学基金[ZR2014HM094]

摘　　要：目的优选逆萎康的最佳提取工艺。方法采用L9(34)正交试验方法,以雪胆总皂苷、黄芪甲苷含量为指标,考察提取次数、提取时间及固液比因素对逆萎康提取效果的影响,优选提取工艺。结果逆萎康的最佳工艺条件为提取2次,提取1 h,固液比12倍。结论该提取工艺操作简便、准确,可为逆萎康颗粒剂的制备提供参考。Objective To optimize the water extraction process of Niweikang.Methods L9(34)orthogonal test was adopted,the effects of extraction times,extraction time and solid-liquid ratio on the extraction efficiency of Niweikang were investigated with the contents of total saponins from Hemsleya amabilis and astragalosideⅣas indexes,and the extraction process was optimized.Results The conditions of the optimum process was as follows:extracting 1 h for 2 times with the solid-liquid ratio of 12 times.Conclusion The extraction process is simple and accurate,which can provide a reference for the preparation of Niweikang Granules.

关 键 词：逆萎康 雪胆总皂苷 黄芪甲苷 正交试验 提取工艺 

分 类 号：R932[医药卫生—生药学] R284.1[医药卫生—药学]