270例中成药不良反应Pareto最优分析  

Pareto Optimal Analysis of 270 Cases of Adverse Reactions Induced by Chinese Patent Drugs

作　　者：郭虎[1] GUO Hu(Department of Pharmacy,Chongqing Three Gorges Central Hospital,Chongqing,China 404000)

机构地区：[1]重庆三峡中心医院药学部,重庆404000

出　　处：《中国药业》2019年第5期87-89,共3页China Pharmaceuticals

摘　　要：目的探讨中成药药品不良反应(ADR)的一般规律和特点。方法选取医院2012年至2016年使用中成药所致的270例ADR患者,分别从患者年龄与性别、给药途径、ADR类型、ADR累及器官/系统等进行Pareto最优分析。结果年龄≥41岁患者发生ADR最多(占66. 67%),给药途径主要为口服(占70. 37%),ADR类型主要为新的一般ADR(占53. 33%),ADR主要临床表现为累及皮肤及其附件和消化系统(78. 52%)。结论临床医师、药师应了解中成药ADR的规律和特点,加强其应用监测,减少ADR的发生率,确保临床用药安全、有效。Objective To investigate the general pattern and characteristics of adverse drug reactions(ADRs)induced by Chinese patent drugs.Methods Totally 270 cases of ADRs induced by Chinese patent drugs occurred in our hospital from 2012 to 2016 were selected,and Pareto optimal analysis was carried out from the age and sex,route of administration,type of ADR,organ/system involvement of ADR.Results Among 270 cases of ADR reports,the majority were people aged≥41 years old(66.67%),the main route of administration causing ADR was oral(70.37%),the main ADR type was new and general ADR(53.33%),the clinical manifestations of ADR were mainly lesions of skin and digestive system(78.52%).Conclusion Clinical physicians and pharmacists should understand the pattern and characteristics of ADRs induced by Chinese patent drugs,and strengthen monitoring of its use,in order to reduce the incidence of ADRs,and ensure the safety and effectiveness of clinical medication.

关 键 词：中成药 药品不良反应 Pareto最优分析 合理用药 

分 类 号：R932[医药卫生—生药学] R288[医药卫生—药学]