呼出气挥发性有机化合物在临床转化医学中的应用  

Application of exhaled volatile organic compounds in clinical transformation medicine

作　　者：白杨[1] 郭雷[1] 李恩有[1] BAI Yang;GUO Lei;LI Enyou(Anesthesiology,The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院麻醉科,黑龙江哈尔滨150001

出　　处：《安徽医药》2019年第3期615-620,共6页Anhui Medical and Pharmaceutical Journal

摘　　要：人体呼出气中含有数千种挥发性有机化合物,反映着体内的代谢状况。近年来呼出气分析技术由于它的方便,安全,无创和无痛等优点,使它在临床诊断和监测领域中备受关注。多项研究表明,特异性的挥发性有机化合物与某些疾病存在相关性,可作为疾病诊断的生物标志物。该文总结了与癌症(如肺癌、乳腺癌),代谢性疾病(如糖尿病),氧化应激(如慢性阻塞性肺疾病和哮喘)以及神经系统性疾病(如肌萎缩侧索硬化症、帕金森病)相关的一些呼出气中重要的生物标志物以及产生的病理生理机制。同时简述了呼出气分析技术在临床应用中面临的主要问题。The human exhaled breath contains thousands of volatile organic compounds(VOCs)that reflect the metabolism of human body.In recent years breath analysis,as one of the convnient,safe,noninvasive and painlessness technique,attracts more attention when applying to clinical diagnosis and monitoring of diseases.Severial studies have show that specific volatile organic compounds are associated with certain diseases and can be used as biomakers.This article summarizes some important breath biomakers and their pathophysiological mechanisms associated with cancer(such as lung cancer,breast cancer),metabolic diseases(such as diabetes)oxidative stress(such as chronic obstructive pulmonary disease and asthma)and neurological diseases(such as amyotrophic lateral sclerosis,Parkinson′s disease).The main problems in the clinical application of exhaled air analysis are also discussed.

关 键 词：呼出气 生物标志物 挥发性有机化合物 

分 类 号：R44[医药卫生—诊断学]