改善心肌肌质网钙泵防治慢性心力衰竭的中医药研究进展  

Research progress on improving myocardial sarcoplasmic reticulum calcium ATPase 2a with the treatment of traditional Chinese medicine in chronic heart failure

作　　者：李惠玲 贾美君[1] 刘永明[1] LI Huiling;JIA Meijun;LIU Yongming(Department of Cardiology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院心血管内科,上海201203

出　　处：《中国医药导报》2019年第4期55-58,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81102671);国家自然科学基金资助项目(81603581);上海市卫生和计划生育委员会项目资助(201640167)

摘　　要：慢性心力衰竭(CHF)是多种心血管疾病发展的终末阶段,发病率及病死率高,治疗费用昂贵。心肌细胞肌质网钙泵(SERCA2a)表达及活性异常是CHF发生、发展的重要病理机制。AAV1/SERCA2a转基因治疗CHF临床试验结果不尽如人意,研究者重新提出"应充分重视提高内源性心肌SERCA2a水平及活性的药物筛选及研发"。中医药治疗CHF历史悠久,效果显著。CHF在中医学中可归属于"心悸""喘证""水肿"等范畴。大量研究表明中药复方、单味中药、中药单体能有效改善内源性心肌SERCA2a表达水平及活性从而起到防治CHF的作用。Chronic heart failure(CHF)is the end stage of a variety of cardiovascular diseases,with high incidence,high mortality and expensive treatment.The abnormal expression and activity of cardiac myocyte sarcoplasmic reticulum calcium ATPase 2a(SERCA2a)are the key pathological mechanism for the occurrence and development of CHF.The results of the clinical trial that AAV1/SERCA2a genetically treats CHF were not satisfactory,and the researchers restated that full attention should be paid to drug screening,research and development to improve the endogenous myocardial SERCA2a expression level and activity.Traditional Chinese medicine has a long history in treating CHF with remarkable therapeutic effects.In traditional Chinese medicine,CHF can be classified to the cotogories of"palpitation","asthma syndrome"and"edema".A lot of researches indicate that Chinese medicine compound,single Chinese herb and Chinese medicine monomer can prevent and treat CHF through improving endogenous myocardial SERCA2a expression and activity.

关 键 词：慢性心力衰竭 肌质网钙泵 蛋白表达 基因表达 活性 

分 类 号：R541[医药卫生—心血管疾病]