糖尿病肾病患者炎症因子的表达及与肾功能指标的相关性分析  

Expression of inflammatory factors in patients with diabetic nephropathy and their correlation with renal function

作　　者：张圭[1] 杨溢[1] 陆秀红[1] ZHANG Gui;YANG Yi;LU Xiu-hong(Geriatric Cadre Ward,Guangdong General Hospital of Armed Police,Guangdong Province,Guangzhou 510507,China)

机构地区：[1]武警广东总队医院老年干部病区,广东广州510507

出　　处：《中国当代医药》2019年第5期67-69,共3页China Modern Medicine

摘　　要：目的探讨糖尿病肾病患者炎症因子的表达及与肾功能指标的相关性。方法选取2016年2月～2018年8月我院收治的90例糖尿病患者作为研究对象,按照24 h尿微量清蛋白排泄率不同分为三组,即观察1组(正常清蛋白尿)、观察2组(微量清蛋白尿)、观察3组(临床清蛋白尿),每组各30例,选择同期30例健康体检人员作为对照组。比较四组血清中炎症因子(C反应蛋白、白介素-6、细胞肿瘤坏死因子-α)及肾功能指标[血肌酐、血胱抑素C、尿清蛋白排泄率(UAER)],采用Pearson相关分析确定炎症因子与肾功能的关系。结果观察组C反应蛋白、白介素-6、细胞肿瘤坏死因子-α、血肌酐、血胱抑素C、UAER水平高于对照组,差异均有统计学意义(P<0.05);观察3组血清中炎症因子水平高于观察1、2组,差异均有统计学意义(P<0.05)。C反应蛋白、白介素-6、细胞肿瘤坏死因子-α与血肌酐、血胱抑素C、UAER成正相关(P<0.05)。结论糖尿病患者机体内的炎症因子水平与肾脏病变存在相关性。Objective To investigate the expression of inflammatory factors in patients with diabetic nephropathy and its correlation with renal function.Methods Ninety patients with diabetes mellitus admitted to our hospital from February 2016 to August 2018 were selected as the research objects,according to the 24-hour urinary microalbuminuria excretion rate,they were divided into three groups,observation group 1(normal albuminuria),observation group 2(microalbuminuria)and observation group 3(clinical albuminuria),thirty patients in each group were selected as the control group.The levels of serum inflammatory factors(C-reactive protein,interleukin-6,tumor necrosis factor-α)and renal function indexes(serum creatinine,cystatin C,urinary albumin excretion rate(UAER)were compared among the four groups.Pearson correlation analysis was used to determine the relationship between inflammatory factors and renal function.Results The levels of C-reactive protein,interleukin-6,tumor necrosis factor-α,serum creatinine,cystatin C and UAER in the observation group were significantly higher than those in the control group,the differences were significant(P<0.05).The levels of inflammatory factors in serum of the observation groups 3 were higher than those of the observation groups 1 and 2,the differences were significant(P<0.05).C-reactive protein,interleukin-6 and tumor necrosis factor-αwere positively correlated with serum creatinine,cystatin C and UAER(P<0.05).Conclusion There is a correlation between the levels of inflammatory factors and renal lesions in patients with diabetes mellitus.

关 键 词：糖尿病 炎症因子 肾脏病变 

分 类 号：R587.1[医药卫生—内分泌]