大剂量羟考酮缓释片治疗晚期癌性疼痛的效果  

Effect of high dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain

作　　者：周瑜 李玲 李洁 ZHOU Yu;LI Ling;LI Jie(Department of Oncology,the Second People′s Hospital of Pingxiang City in Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市第二人民医院肿瘤科,江西萍乡337000

出　　处：《中国当代医药》2019年第5期77-79,共3页China Modern Medicine

摘　　要：目的探讨大剂量羟考酮缓释片治疗晚期癌性疼痛的效果。方法选取我院2017年4月～2018年4月收治的48例晚期癌症疼痛患者作为临床研究对象,根据治疗方法不同将其分为对照组(n=24)和观察组(n=24)。对照组采用硫酸吗啡缓释片镇痛治疗,观察组采用大剂量(120～280 mg)盐酸羟考酮缓释片镇痛治疗。比较两组患者治疗前与治疗15 d后的NRS评分以及镇痛效果和不良反应发生情况。结果两组患者治疗前的NRS评分比较,差异无统计学意义(P>0.05)。两组治疗15 d后的疼痛数字评分法(NRS)评分与治疗前比较均显著降低(P<0.05),且与对照组比较,观察组治疗后的NRS评分下降程度更明显(P<0.05)。观察组患者治疗15 d后的镇痛总有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组的不良毒副作用总发生率明显低于对照组,差异有统计学意义(P<0.05)。结论大剂量羟考酮缓释片治疗晚期癌性疼痛患者疗效可靠,镇痛效果明显,不良副作用少,安全性好,值得临床借鉴和推广应用。Objective To explore the efficacy of high-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain.Methods A total of 48 patients with advanced cancer pain admitted to our hospital from April 2017 to April 2018 were selected as the study subjects.They were divided into the control group(n=24)and the observation group(n=24)according to different treatment methods.The control group was treated with Morphine Sulfate Sustained-Release Tablets,while the observation group was treated with high-dose(120-280 mg)Oxycodone Hydrochloride Sustained-Release Tablets.The pain digital scoring method(NRS)scores,analgesic effects and adverse reactions were compared between the two groups before treatment and 15 days after treatment.Results There was no statistically significant difference in the NRS score between the two groups before treatment(P >0.05).The NRS scores of the two groups after 15 d treatment were significantly lower than those before treatment(P<0.05).Compared with the control group,the NRS score of the observation group decreased more significantly after treatment(P<0.05).The total effective rate of analgesia in the observation group was significantly higher than that in the control group after 15 days of treatment,with significant difference(P<0.05).The total incidence of adverse drug reactions in the observation group was significantly lower than that in the control group,with significant difference(P<0.05).Conclusion High-dose Oxycodone Sustained-Release Tablets in the treatment of advanced cancer pain patients have reliable efficacy,with obvious analgesic effect,less adverse reactions,good safety,it is worthy of clinical reference and application.

关 键 词：晚期癌症疼痛 硫酸吗啡缓释片 大剂量羟考酮缓释片 效果 安全性 

分 类 号：R979.9[医药卫生—药品]