舒心贴膏的制备工艺优选  

Optimization of preparation process of Shuxin plaster

作　　者：葛重宇 李俊松[1] GE Chong-yu;LI Jun-song(Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023, China;Wuxi Third People's Hospital, Jiangsu Wuxi 214000, China)

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]无锡市第三人民医院药学部,江苏无锡214000

出　　处：《临床医药文献电子杂志》2019年第11期29-31,33,共4页Electronic Journal of Clinical Medical Literature

摘　　要：目的优选舒心贴膏的制备工艺。方法以丹参酮ⅡA的提取量为指标,HPLC测定指标成分含量,采用正交试验设计考察浸渍时间、乙醇用量及渗漉速率等因素的影响,综合评分法优选舒心贴膏的提取工艺。以药粉封装材料、药物库的成型、药物库载药粉末、润湿剂处方、辅料为指标,选择最优成型工艺参数。结果得出舒心贴膏的最佳提取工艺和最佳成型工艺。结论该优选的制备工艺合理、可行,适用于工业化生产。Objective Preferred preparation process of Shuxin paste. Methods Taking the extraction amount of tanshinone IIA as the index, the content of the indicator component was determined by HPLC. The effects of immersion time, ethanol dosage and percolation rate were investigated by orthogonal design. The comprehensive scoring method was used to optimize the water extraction process of Shuxin paste. Selecting the optimal molding process parameters by using the powder packaging material, the molding of the drug library, the drug-loaded drug powder, the wetting agent prescription and the auxiliary materials as indicators. Results Summarized the best extraction process and the best molding process of Shuxin plaster. Conclusion The preferred preparation process is reasonable and feasible, and is suitable for industrial production.

关 键 词：舒心贴膏 正交实验 水提工艺 成型工艺 

分 类 号：R94[医药卫生—药剂学]