去势雌兔骨质疏松模型的建立  

Establishment of osteoporosis model in ovariectomized rabbits

作　　者：王熙 张浩[1] 张璐 郭浩 何志伟 李博然 王星 王希 李志军 WANG Xi;ZHANG Hao;ZHANG Lu;GUO Hao;HE Zhi-wei;LI Bo-ran;WANG Xing;WANGXi;LI Zhi-jun(The first clinical medical college of Inner Mongolia Medical University,Neimenggu Huhehaote 010110,China;Department of anatomy,School of Basic Medical Sciences,Inner Mongolia Medical University,Neimenggu Huhehaote 010110,China;Shandong military region Ji'nan second retired cadre sanatorium Health Institute,Shandong Ji'nan 250014,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010110 [2]内蒙古医科大学基础医学院解剖学教研室,内蒙古呼和浩特010110 [3]山东省军区济南第二离职干部休养所门诊部,山东济南250014

出　　处：《临床医药文献电子杂志》2019年第13期6-7,10,共3页Electronic Journal of Clinical Medical Literature

基　　金：内蒙古医科大学大学生科技创新"英才培育"项目(2017032)

摘　　要：目的探讨采用去势法建立雌免骨质疏松症模型3月能否建模成功。方法 32只6月龄日本大耳白雌兔随机分成手术组(OVX)与假手术组S(HAM),前者行双侧卵巢切除术怒,后者按步骤切开腹腔后缝合,术后3个月检测并分析兔各部位骨密度变化。结果术后组3个月去势后测量发现头部骨密度明显较正常对照组低(P<0.05),但身体其他部位(上下肢、脊柱等)变化均不明显(P>0.05),全身骨密度变化不明显(P> 0.05)。结论去势法建立日本大耳白兔骨质疏松症模型3个月时不能完成全身骨质疏松模型,只有头部3个月后表现出骨密度降低情况,为今后骨质疏松建模提供一定理论依据。Objective To explore the feasibility of establishing a female osteoporosis model by castration in March. Methods Thirty-two six-month-old Japanese white rabbits were randomly divided into operation group (OVX) and sham operation group S (HAM).The former underwent bilateral ovariectomy, the latter underwent step-by-step incision and suture.The changes of bone mineral density in each part of the rabbit were detected and analyzed 3 months after operation. Results Bone mineral density of head was significantly lower than that of normal control group after 3 months castration ( P < 0.05),but the changes of other parts of the body (upper and lower limbs,spine,etc.) were not obvious ( P > 0.05),and the changes of systemic BMD were not obvious ( P > 0.05). Conclusion Osteoporosis model of Japanese big-eared rabbits can not be established by castration for 3 months. Only three months after the head showed a decrease in bone mineral density,providing a theoretical basis for the future modeling of osteoporosis.

关 键 词：去势法 骨质疏松模型 骨质疏松症 雌兔 

分 类 号：R681[医药卫生—骨科学]