连续性血液净化治疗脓毒症的效果观察  

Observation on the effect of continuous blood purification on sepsis

作　　者：黄高[1] 李军[1] 尧国胜[1] 黄忠仕[1] 吴晓文[1] 韦凌云 农进 Huang Gao;Li Jun;Yao Guosheng;Huang Zhongshi;Wu Xiaowen;Wei Lingyun;Nong Jin(Intensive Care Unit,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院重症医学科,广西百色533000

出　　处：《右江民族医学院学报》2019年第1期58-60,共3页Journal of Youjiang Medical University for Nationalities

基　　金：右江民族医学院附属医院临床医学博士学位授权点学科建设项目

摘　　要：目的观察连续性血液净化(CBP)对脓毒症患者的临床效果。方法随机选择我院收治的25例脓毒症患者为对照组(常规治疗),另外选择25例脓毒症患者为观察组(在常规治疗基础上加CBP治疗)。对比两组患者的机械通气时间、APACHEⅡ评分、人高迁移率族蛋白-1(HMG-1)和肿瘤坏死因子-α(TNF-α)水平。结果观察组机械通气时间明显短于对照组,差异有统计学意义(P<0.05);观察组治疗后APACHEⅡ评分、HMG-1、TNF-α水平明显低于对照组,差异有统计学意义(P<0.05)。结论CBP可以缩短脓毒症患者机械通气时间,降低APACHEⅡ评分,HMG-1及TNF-α的水平,值得临床上推广应用。Objective To observe the clinical effect of continuous blood purification(CBP)on sepsis.Methods Twenty-five patients with sepsis cared at our hospital were randomly selected as control group(conventional treatment)and 25 patients with sepsis were selected as observation group(added with CBP based on conventional treatment).The mechanical ventilation time,APACHEⅡscore,human high mobility group protein 1(HMG-1)and tumor necrosis factor-α(TNF-α)levels were compared between the two groups.Results The mechanical ventilation time of observation group was shorter than that of control group,and the difference was statistically significant(P<0.05).The APACHEⅡscore,HMG-1 and TNF-αlevels in the observation group were significantly lower than those in the control group,and the difference by comparing between the two groups was statistically significant(P<0.05).Conclusion Continuous blood purification can shorten the mechanical ventilation time of sepsis patients,and it can also reduce the level of APACHEⅡscore,HMG-1 and TNF-α,which is worthy of clinical application.

关 键 词：脓毒症 连续性血液净化 肿瘤坏死因子-Α 人高迁移率族蛋白-1 

分 类 号：R631[医药卫生—外科学]