稳定烯醇结构3-氯-2-羟基-4-羰基-4-对甲苯基-2-丁烯酸乙酯的合成  

Synthesis of the stable enol ethyl 3-chloro-2-hydroxy-4-oxo-4-(p-tolyl)but-2-enoate

作　　者：徐泽刚[1] 王伦[1] 李秉擘 宁斌科[1] 王月梅[1] 卫天琪 杨翠凤[1] XU Ze-gang;WANG Lun;LI Bing-bo;NING Bin-ke;WANG Yue-mei;WEI Tian-qi;YANG Cui-feng(State Key Laboratory of Fluorine&Nitrogen Chemicals,Xi’an Modern Research Institute,Xi’an 710065,China)

机构地区：[1]西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室,陕西西安710065

出　　处：《化学研究与应用》2019年第2期299-302,共4页Chemical Research and Application

摘　　要：以甲苯为起始原料,通过傅克-酰基化、Aldol反应合成了具有稳定烯醇结构的3-氯-2-羟基-4-羰基-4-对甲苯基-2-丁烯酸乙酯,反应过程生成了中间体3,3-二氯-2-羟基-4-羰基-4-对甲苯基丁酸乙酯,采用红外、核磁共振谱、HRMS产品进行了测定和结构表征。对反应机理进行了初步探讨。The stable enol ethyl 3-chloro-2-hydroxy-4-oxo-4-(p-tolyl)but-2-enoate was synthesized from toluene via Friedel-Crafts acylation and Aldol reaction.Ethyl 3,3-dichloro-2-hydroxy-4-oxo-4-(p-tolyl)but-2-enoate as the intermediate was formed during the reaction.The structure of the title compound was determined and characterized by IR,NMR,and HRMS.The mechanism of reaction was also discussed.

关 键 词：烯醇 3-氯-2-羟基-4-羰基-4-对甲苯基-2-丁烯酸乙酯 乙醛酸乙酯 反应机理 

分 类 号：O621.3[理学—有机化学]