不对称大环双核铜配合物的合成,性质及抗菌活性  

Synthesis,properties and antibacterial activities of asymmetric dinuclear copper(Ⅱ)macrocyclic complex

作　　者：刘焕[1] 刘郁[1] 张雪梅[1] 潘志权 高娟 LIU Huan;LIU Yu;ZHANG Xue-mei;PAN Zhi-quan;GAO Juan(School of Chemical Engineering,Xuzhou College of Industrial Technology,Xuzhou 221140,China;School of Chemistry EnvironmentalEngineering,Wuhan Institute of Technology,Wuhan 430073,China)

机构地区：[1]徐州工业职业技术学院化学工程学院,江苏徐州221140 [2]武汉工程大学化学与环境工程学院,湖北武汉430073

出　　处：《化学研究与应用》2019年第2期314-319,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(20271039)资助;江苏省大学生实践创新计划训练项目(201713107010Y)资助

摘　　要：以配体N,N′-二甲基-N,N′-二(3-甲酰基-5-氯水杨醛)乙二胺(H_2L)与乙二胺、醋酸铜、高氯酸铜通过模板反应缩合制备了新的不对称大环双核铜配合物[Cu_2(L)(ClO_4)·H_2O]·ClO_4,通过元素分析、红外光谱、电喷雾质谱、X-晶体衍射对配合物进行结构表征,表明不对称大环配合物中的一个铜(Ⅱ)离子与大环中两个胺的氮原子、两个酚羟基的氧原子以及高氯酸根中的氧原子形成5配位,另一个铜(Ⅱ)离子与大环中的两个亚胺氮原子、两个酚羟基氧原子以及配位的水分子中的氧原子形成5配位;电化学性质研究表明铜(Ⅱ)离子的电极过程是一个不可逆单电子传递过程,磁性研究表明配合物的铜(Ⅱ)离子之间存在反铁磁性偶合,抗菌实验测试了配体和双核铜(Ⅱ)配合物对金黄色葡萄球菌、绿脓杆菌、大肠杆菌的抗菌活性,结果表明:在质量浓度为2.0g·L^(-1)时,配体和双核铜(Ⅱ)配合物的抗菌活性最强。A new asymmetric dinuclearCopper(Ⅱ)macrocyclic complex[Cu2(L)(ClO4)·H2O]·ClO4,was synthesized by N,N′-dimethyl-N,N′-bis(3-formyl-5-chlorosalicylidene)ethylenediamine(H2L),ethylenediamine,Cu(ClO4)2·6 H2O andCu(OAc)2·H2O.The complex was characterized by elemental analysis,infrared spectroscopy(IR),electrospray ionization mass spectrometry(ES-MS)and X-ray.Crystal structure analysis showed one copper(Ⅱ)ion was five-coordinated by two amino nitrogens,two phenolic oxygens from the macrocyclic ligand,oxygen from the perchlorate anions.Another copper(Ⅱ)ion was five-coordinated by two iminonitrogens,two phenolic oxygens from the macrocyclic ligand,oxygen from the coordinated water.The complex showed a irreversible reduction peak,attributed to the single-electron exchange from Cu(Ⅱ)Cu(Ⅱ)to Cu(Ⅱ)Cu(I)according to the electrochemical studies.The complex showed significant antiferromagnetic interaction within dinuclear unit.The antibacterial activities were screened for the ligand(H2L)and the copper(Ⅱ)complex against three bacteria:Staphylococcus aureus,Pseudomonasaeruginosa and Escherichia coli.The results showed that the ligand(H2L)and the copper(Ⅱ)complex had the most intense antibacterial activities when their mass concentration was 2.0 g·L-1.

关 键 词：不对称大环配合物 双核铜配合物 性质 抗菌活性 

分 类 号：O614.12[理学—无机化学]