丹红注射液对2型糖尿病血瘀证患者胰岛素抵抗的影响  

Effects of Danhong Injection on Insulin Resistance in Type 2 Diabetic Patients with Blood Stasis Syndrome

作　　者：杨丽鸣[1] 邵文妍 赵蓓俊 齐慧娟 孙丹萍[1] 冯继明 Yang Liming;Shao Wenyan;Zhao Beijun;QI Huijuan;Sun Danping;Feng Jiming(Department of Endocrinology,Shanghai Chinese and Western Medicine Hospital,Shanghai 200010,China)

机构地区：[1]上海市黄浦区中西医结合医院内分泌科,上海200010

出　　处：《世界中医药》2019年第2期434-437,共4页World Chinese Medicine

基　　金：上海市第三批中医临床优势专科建设项目(ZYSNXD-YL-YSZKO33)

摘　　要：目的:观察丹红注射液对2型糖尿病血瘀证患者胰岛素抵抗的影响。方法:选取2015年7月至2017年12月2月上海市黄浦区中西医结合医院内分泌科收治的2型糖尿病血瘀证患者60例,按照随机数字表法随机分为观察组和对照组,每组30例。2组均予拜阿司匹林治疗,观察组在此基础上予丹红注射液治疗,分别对2组内治疗前后和2组组间治疗后的血黏度、空腹血糖、空腹胰岛素、IR、胰岛素敏感指数进行比较。结果:与治疗前比较,2组治疗后血黏度、空腹血糖、IR与治疗前比较均明显下降(P <0. 01),2组治疗后空腹胰岛素、胰岛素敏感指数均明显增高(P <0. 01); 2组治疗后血黏度,胰岛素敏感指数差值比较,差异均有统计学意义(P <0. 05或P <0. 01)。结论:丹红注射液能降低2型糖尿病血瘀证患者血黏度,改善胰岛素抵抗,提高胰岛素敏感性。Objective:To observe of the effects of Danhong Injection on insulin resistance in patients with type 2 diabetes and blood stasis syndrome.Methods:A total of 60 cases of type 2 diabetes with blood stasis syndrome in Shanghai Chinese and Western Medicine Hospital from July 2015 to December 2,2017 were divided into 30 cases in the treatment group and the control group.The two groups were treated with aspirin.The treatment group was treated with Danhong Injection on the basis of this.Blood viscosity,fasting blood glucose,fasting insulin,insulin resistance index and insulin sensitivity index were compared between the two groups before and after treatment,and between the 2 groups.Results:The blood viscosity,fasting blood glucose and insulin resistance index of the 2 groups was significantly decreased in the group before and after the treatment(P<0.01).Fasting insulin and insulin sensitivity index of the two groups were significantly increased in the group before and after the treatment(P<0.01).The difference of blood viscosity and insulin sensitivity index between the two groups after treatment was compared.Their differences were statistically significant(P<0.05 or P<0.01).Conclusion:Danhong injection can reduce blood viscosity,improve insulin resistance and increase insulin sensitivity in patients with type 2 diabetes and blood stasis syndrome.

关 键 词：2型糖尿病血瘀证 胰岛素抵抗 丹红注射液 拜阿司匹林 血黏度 空腹血糖 空腹胰岛素 IR 胰岛素敏感指数 

分 类 号：R255.4[医药卫生—中医内科学]