气相色谱法测定克罗拉宾原料中乙酸的残留量  

The residual amount of acetic acid in Clofarabine by gas chromatography

作　　者：安晏[1] 邢丽舟 AN Yan;XING Li-zhou(Anyang Vocational And Technical College,Henan Anyang 455000,China)

机构地区：[1]安阳职业技术学院,河南安阳455000

出　　处：《临床医药文献电子杂志》2019年第5期167-167,169,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的建立气相色谱法测定克罗拉滨原料药中乙酸的残留量。方法采用气相色谱法,色谱柱为PorapaK Q高分子小球填充柱(2 mm×3 m),载气为氮气,检测器为氢火焰离子化检测器。结果在该法采用的色谱条件下,测定溶剂线性关系、精密度、准确度、灵敏度均达到了预定的分析要求,在克罗拉滨原料药中未检出乙酸残留。结论本法能快速准确的对乙酸残留进行检测,可用于克罗拉滨原料药质量控制中的乙酸残留溶剂检查。Objective To establish a method for the limit test of acetic acid in Clofarabine.Methods Gas chromatography(GC)determination was employed and chroma-tographic column was capillary column PorapaK Q(2 mm×3 m),with FID detector andnitrogen as carrier gas.Results The solvents can be completely separated and good linear relationship within a certain range.Conclusion The method is easy to apply in detection of acetic acid in Clofarabine.

关 键 词：克罗拉宾 乙酸 气相色谱法 

分 类 号：R917[医药卫生—药物分析学]