老年宫颈癌患者血清NO、Gal-9表达及其与细胞凋亡的相关性研究  

Study on the expression of serum NO and Gal-9 and its correlation with apoptosis in elderly patients with cervical cancer

作　　者：刘爱萍[1] 胡洁[2] LIU Aiping;HU Jie(Clinical Testing Center,Gansu Maternal and Child Health Care Hospital,Lanzhou,Gansu 730050,China;Plastic Surgery Department,Gansu Maternal and Child Health Care Hospital,Lanzhou,Gansu 730050,China)

机构地区：[1]甘肃省妇幼保健院临床检验中心,甘肃兰州730050 [2]甘肃省妇幼保健院整形美容科,甘肃兰州730050

出　　处：《国际检验医学杂志》2019年第4期403-406,共4页International Journal of Laboratory Medicine

基　　金：甘肃省自然科学研究基金计划(1208RJZA122)

摘　　要：目的探讨分析老年宫颈癌患者血清一氧化氮(NO)、半乳凝素-9(Gal-9)表达及其与细胞凋亡的相关性。方法选择该院收治的76例老年宫颈癌患者作为宫颈癌组,50例老年子宫颈上皮不典型增生(CIN)患者作为CIN组,50例健康老年人群作为健康对照组,采用流式细胞技术检测3组受试者组织细胞凋亡(AI)指数,检测3组受试者血清NO、Gal-9水平,比较分析3组受试者各指标差异及相关性,并分析宫颈癌患者血清NO、Gal-9水平与病理特征关系。结果 3组受试者AI指数比较,差异具有统计学意义(P<0.05),其中宫颈癌组患者AI指数明显高于健康对照组,但明显低于CIN组,差异具有统计学意义(P<0.05)。3组受试者血清NO、Gal-9水平比较,差异具有统计学意义(P<0.05),且宫颈癌组患者血清NO、Gal-9水平明显高于健康对照组与CIN组,差异具有统计学意义(P<0.05)。宫颈癌患者血清NO、Gal-9水平均与AI指数呈正相关(r分别为0.813、0.872,P<0.05)。宫颈癌临床分期Ⅲ、Ⅳ期患者血清NO、Gal-9水平明显高于Ⅰ、Ⅱ期患者,差异具有统计学意义(P<0.05),肿瘤低分化患者血清Gal-9水平明显高于中、高分化患者,差异具有统计学意义(P<0.05)。结论血清NO、Gal-9参与到了老年宫颈癌发生发展过程中,同时对宫颈癌组织细胞凋亡发挥一定的影响作用,其具体影响机制还需进一步深入研究分析。Objective To investigate and analyze the expression of serum NO and Gal-9 and its correlation with apoptosis in elderly patients with cervical cancer.Methods 76 cases of elderly patients with cervical cancer in our hospital as the cervical cancer group,50 cases of cervical epithelial dysplasia of uterus in elderly(CIN)were taken as CIN group and 50 healthy elderly people as healthy controls were detected by flow cytometry in three subjects tissue apoptosis index(AI)and the detection of serum NO and Gal-9 levels in three groups of subjects,difference analysis and correlation of the indicators of the three groups of subjects,and analyze the relationship between the serum of patients with cervical cancer NO,Gal-9 levels and pathological features.Results There was a significant difference in the tissue apoptosis index(AI)between the three groups(P﹤0.05),and the AI index in the cervical cancer group was significantly higher than that in the healthy control group(P﹤0.05),but it was significantly lower than that in the CIN group(P﹤0.05).The serum NO and Gal-9 levels of the three groups were statistically different(P﹤0.05),and the levels of NO and Gal-9 in the cervical cancer group were significantly higher than those in the healthy control group and CIN group(P﹤0.05).The serum levels of NO and Gal-9 in patients with cervical cancer were positively correlated with the value of AI(r=0.813,0.872,P﹤0.05).The serum NO and Gal-9 levels in patients with stageⅢandⅣof cervical cancer were significantly higher than those inⅠandⅡpatients(P﹤0.05).The serum Gal-9 level in patients with poorly differentiated tumors was significantly higher than that in patients with high or intermediate differentiation(P﹤0.05).Conclusion Serum NO and Gal-9 play an important role in the occurrence and development of cervical cancer in elderly patients,and play a certain role in the apoptosis of cervical cancer tissues.The specific mechanisms of their effects need further research and analysis.

关 键 词：老年 宫颈癌 一氧化氮 半乳凝素9 细胞凋亡 

分 类 号：R446.11[医药卫生—诊断学]