ANCA、IL-1、IL-6、TNF-α四项检测诊断类风湿性关节炎的研究进展  

Research progress of combined rheumatoid factor ANCA,IL-1,IL-6,TNF-αdetection in diagnosing rheumatoid arthritis

作　　者：舒碧莹 蒋麒俊 蔡枫[1] SHU Biying;JIANG Qijun;CAI Feng(Department of Clinical Laboratory,Affiliated Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院检验科,上海200071

出　　处：《国际检验医学杂志》2019年第4期448-452,共5页International Journal of Laboratory Medicine

基　　金：上海申康医院发展中心市级医院临床辅助科室能力建设项目(SHDC22014009)

摘　　要：类风湿性关节炎是一种以累及关节为主的慢性自身免疫性疾病,具有全身性炎性反应特点。研究表明,相关抗中性粒细胞胞浆抗体(ANCA)阳性,炎症因子白细胞介素(IL)-1、IL-6、肿瘤坏死因子(TNF)-α的增高在类风湿性关节炎患者的炎性反应过程中发挥重要作用。类风湿性关节炎患者ANCA阳性和炎症因子IL-1、IL-6、TNF-α增高,与中医痹病之风湿热痹发病机制基本吻合。对类风湿性关节炎的治疗上,西医使用甲氨蝶呤(MTX)作为基础药物,联合其他药物,在疾病稳定期复查ANCA、IL-1、IL-6、TNF-α可观其渐趋于正常。再结合中医清热除湿治法,可增强西医疗效及减轻西药副作用,稳定类风湿性关节炎病情同时,使异常的ANCA、IL-1、IL-6、TNF-α长期稳定在正常范围。因此,研究ANCA、IL-1、IL-6、TNF-α有助于类风湿性关节炎诊断及治疗。Rheumatoid Arthritis is a kind of chronic autoimmune diseases mainly involving joint,which is characterized by systemic inflammatory response.Studies have shown that Rheumatoid arthritis patients showed associated antineutrophil cytoplasmic antibody(ANCA)and inflammatory cytokines such as interleukin(IL),tumor necrosis factor(TNF)increased,the positive of ANCA and the increase of IL-1,IL-6,TNF-αare especially seen in the Rheumatoid arthritis patients who have inflammatory reaction,and which are roughly equal to the articular synovitis pathological mechanism of wind dampmess heat accumulation pattern in the traditional Chinese medicine.The treatment for Rheumatoid arthritis patients,Western treatment is use the methotrexate(MTX)as basic drugs,combined with other drugs to control the positive of ANCA and the higher of IL-1,IL-6,TNF-α.And combining traditional Chinese medicine treatment,the effect is not only at to increase Western effection but also be able to reduce the side effects of Western medicine.Therefore,the research of combined rheumatoid factor ANCA,IL-1,IL-6,TNF-αdetection is benefit to diagnosing rheumatoid arthritis.

关 键 词：类风湿性关节炎 抗中性粒细胞胞浆抗体 白细胞介素 肿瘤坏死因子-Α 中西医结合 

分 类 号：R593.22[医药卫生—内科学]