电针联合乌梅丸加减治疗干燥综合征的临床研究  

Clinical study on treatment of Sjogren's syndrome by electroacupuncture combined with wumei pill addition and subtraction

作　　者：冯艳广[1] 魏琴[1] 李长红 魏思璐 吴树君[1] 崔小灿[1] 李坤[1] 王俊丽[1] 王慧娟[1] FENG Yanguang;WEI Qin;LI Changhong;WEI Silu;WU Shujun;CUI Xiaocan;LI Kun;WANG Junli;WANG Huijuan(Department of Rheumatology, Xinxiang First People’s Hospital, Xinxiang Henan 453000, China)

机构地区：[1]新乡市第一人民医院风湿免疫科,河南新乡453000

出　　处：《临床与病理杂志》2018年第12期2621-2626,共6页Journal of Clinical and Pathological Research

基　　金：河南省中医药科学研究专项课题(2016ZY3055)~~

摘　　要：目的:观察电针联合乌梅丸加减治疗干燥综合征的临床疗效和安全性。方法:将76例干燥综合征患者随机分为2组,对照组36例,硫酸羟氯喹治疗;治疗组40例,在对照组用药基础上,给予电针联合乌梅丸加减治疗。疗程12周。观察两组治疗前后临床中医症候疗效,Shirmer试验,唾液流率,CRP,IgG,ESR等指标变化。结果:治疗后,治疗组中医证候疗效明显优于对照组,差别有显著统计学意义(P<0.05)。治疗组患者Shirmer试验、唾液流率及CRP,IgG,ESR较治疗前均有明显改善(P<0.05);对照组患者Schimer试验、唾液流率、CRP较治疗前改善(P<0.05)。各项观察指标对比,治疗组均优于对照组(P<0.05)。安全性方面,两组患者不良反应少,对症治疗后均得到缓解。结论:电针、乌梅丸加减联合硫酸羟氯喹治疗干燥综合征具有协同作用,疗效肯定,安全性高,不良反应少。Objective: To observe the clinical efficacy and safety of electroacupuncture combined with wumu pill in the treatment of Sjogren’s syndrome. Methods: Seventy-six cases of Sjogren’s syndrome were randomly divided into 2 groups, and 36 cases in the control group were treated with hydroxychloroquine sulfate;40 cases in the treatment group were treated with electroacupuncture combined with wumei pill based on the control group. A course of 12 weeks. Changes in clinical TCM syndromes, Shirmer test, saliva flow rate, CRP, IgG and ESR were observed before and after treatment in the two groups. Results: After the treatment, the curative effect of TCM syndrome was compared, and the treatment group was significantly better than that of the control group, with statistically significant differences (P<0.05). Shirmer test, saliva flow rate, CRP, IgG and ESR were significantly improved in the treatment group compared with those before treatment (P<0.05). The Schimer test, saliva flow rate, and CRP of the control group were improved compared with those before treatment (P<0.05). All the observation indexes were compared, and the treatment group was superior to the control group (P<0.05). In terms of safety, adverse reactions were less in both groups, and symptomatic treatment was relieved. Conclusion: The combined treatment of Sjogren’s syndrome with electroacupuncture and umei pill plus or minus hydroxychloroquine sulfate has synergistic effect, positive effect, high safety and less adverse reactions.

关 键 词：干燥综合征 电针 乌梅丸加减 

分 类 号：R259[医药卫生—中西医结合]