经腹部彩超联合血清β-HCG及ALP水平检测在宫外孕早期诊断中的应用价值  

Diagnosis Value of Serum β-HCG ALP Combined Transabdominal Color Doppler Ultrasound for Early Ectopic Pregnancy

作　　者：刘爱华[1] 王东[1] 姚水平[1] 于秀芝[1] 张慧[1] LIU Aihua;WANG Dong;YAO Shuiping(Hengshui People's Hospital/Halixun International Peace Hospital,Hebei Hengshui 053000,China)

机构地区：[1]河北省衡水市人民医院/哈励逊国际和平医院产科,河北衡水053000

出　　处：《河北医学》2019年第2期197-201,共5页Hebei Medicine

摘　　要：目的:探究血清β-人绒毛膜促性腺激素(β-HCG)及碱性磷酸酶(ALP)水平检测联合经腹部彩超在宫外孕早期诊断中的应用价值。方法:选取2017年3月至2018年3月在我院产科诊治的宫外孕患者47例为宫外孕组,同期选取正常妊娠孕妇51例作为正常妊娠组,回顾性分析各研究对象血清中β-HCG、ALP水平和经腹部彩超测得的子宫内是否有孕囊、内膜厚度等指标并进行比较。结果:宫外孕组腹痛、阴道出血、腹部压痛、子宫增大、附件区压痛、宫颈举痛等发生率显著高于正常妊娠组(P<0.05)。宫外孕组患者血清β-HCG水平显著低于正常妊娠组[(1554.12±279.21) vs (3267.98±610.21)mIU/mL,P <0.05];血清ALP水平明显低于正常妊娠组[(29.45±5.23) vs (42.37±9.72) mIU/mL,P <0.05]。Spearman检验结果显示,宫外孕组患者血清β-HCG与ALP水平呈明显正相关(r=0.630,P <0.05)。宫外孕组子宫内膜厚度≤10mm、附件区有包块、宫内无孕囊、无胎心搏动等发生率明显高于正常妊娠组(P<0.05)。血清β-HCG、ALP检测联合经腹部彩超检测诊断宫外孕特异性较高,为96.08%。结论:血清β-HCG、ALP指标联合经腹部彩超检测可明显提高宫外孕早期诊断的特异性,具有一定临床推广意义。Objective:To investigate the value of serumβ-human chorionic gonadotropin(β-HCG),alkaline phosphatase(ALP)and transabdominal color doppler ultrasound in the diagnosis of ectopic pregnancy.Methods:A total of 47 patients with ectopic pregnancy in our hospital from March 2017 to March 2018 were selected.51 pregnant women with normal pregnancy were selected as controls.Retrospective analysis of serumβ-HCG,ALP level and the gestational sac,endometrial thickness and other indicators detected by transabdominal color Doppler ultrasound and compared.Results:The incidence of abdominal pain,vaginal bleeding,abdominal tenderness,uterine enlargement,attachment tenderness and cervical lift were significantly higher in ectopic pregnancy group than that in normal pregnancy group(P<0.05).The level of serumβ-HCG in ectopic pregnancy group was significantly lower than that in normal pregnancy group[(1554.12±279.21)vs(3267.98±610.21)mIU/mL,P<0.05].The level of serum ALP in ectopic pregnancy group was significantly lower than those in the normal pregnancy group[(29.45±5.23)vs(42.37±9.72)mIU/mL,P<0.05].Spearman test showed that serumβ-HCG level was positively correlated with ALP level in ectopic pregnancy group(r=0.630,P<0.05).The incidence of endometrial thickness≤10mm,attachment area with mass,intrauterine no gestational sac,fetal heart rate in ectopic pregnancy group was significantly higher than that of the normal pregnancy group(P<0.05).The of serumβ-HCG and ALP in combination with abdominal color Doppler ultrasonography were 96.08%,which were higher than those used one of them(P<0.05).Conclusion:Combined serumβ-HCG,ALP with abdominal color Doppler ultrasonography can significantly improve the diagnosis rate of early ectopic pregnancy,which is valuable to promote.

关 键 词：Β-人绒毛膜促性腺激素 碱性磷酸酶 经腹部彩超 宫外孕 

分 类 号：R714.22[医药卫生—妇产科学]