早期颅内动脉瘤夹闭术对颅内动脉瘤患者术后血清炎性因子水平变化及并发症发生率的影响  

Effects of Early Intracranial Aneurysm Clipping on Serum Inflammatory Cytokines Levels and Complication Rate in Patients with Intracranial Aneurysms

作　　者：王旭[1] 陈锋[1] 周达全[1] 曾月成 彭鹏[1] 王志勇[1] WANG Xu;CHEN Feng;ZHOU Daquan(Xiangyang Central Hospital/Affiliated Hospital of Hubei College of Arts and Sciences,Hubei Xiangyang 441021,China)

机构地区：[1]湖北省襄阳市中心医院/湖北文理学院附属医院神经外科,湖北襄阳441021

出　　处：《河北医学》2019年第2期208-211,共4页Hebei Medicine

基　　金：湖北省自然科学基金项目;(编号:2015CFB063)

摘　　要：目的:探讨早期颅内动脉瘤夹闭术在颅内动脉瘤中应用价值。方法:选取2015年2月至2017年3月襄阳市中心医院收治的颅内动脉瘤患者72例,随机数字表法分组,各36例。对照组采用血管内栓塞术,研究组采用早期颅内动脉瘤夹闭术。术前及术后1个月统计对比两组神经功能评分(NIHSS)与日常生活能力评分(BI)、血清炎性因子TNF-α、IL-1、IL-6水平变化情况、术后1个月并发症发生率、术后12个月预后情况。结果:两组术后BI分值较术前增高,NIHSS分值较术前降低,且研究组BI分值高于对照组,NIHSS分值低于对照组(P<0.05);术后两组血清TNF-α、IL-1、IL-6水平较术前降低,且研究组低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率11.12%(4/36)低于对照组33.35%(12/36),差异有统计学意义(P<0.05);研究组恢复良好率61.11%(22/36)高于对照组30.56%(11/36),差异有统计学意义(P <0.05)。结论:采用早期颅内动脉瘤夹闭术治疗颅内动脉瘤患者效果显著,可有效降低血清炎性因子水平,改善患者神经功能及日常生活能力,提高预后效果,且安全性较高,具有推广价值。Objective:To investigate the application value of early intracranial aneurysm clipping in patients with intracranial aneurysms.Methods:72 patients with intracranial aneurysms from February 2015 to March 2017 in Xiangyang central hospital were randomly divided into groups,36 cases in each groups.The control group was treated with intravascular embolization,and the study group was treated with early intracranial aneurysm.Neurological function score(NIHSS)and daily life ability score(BI),serum inflammatory factor TNF-α,IL-1 and IL-6 levels preoperative and postoperative 1 month,the incidence of complications1 month after operation and the prognosis12 months after operation were statistically compared between the two groups.Results:The BI scores of the two groups after operation were higher than those before operation,while the NIHSS scores were lower than those before operation;the score of BI in the study group was higher than that in the control group,and the NIHSS score was lower than that in the control group(P<0.05);The serum TNF-α,IL-1 and IL-6 levels in the two groups after operation were lower than those before the operation,and the study group was lower than the control group,the difference was statistically significant(P<0.05);The incidence of complication in the study group 11.12%(4/36)was lower than that of the control group 33.35%(12/36),the difference was statistically significant(P<0.05);The good recovery rate of the study group 61.11%(22/36)was higher than that of the control group(30.56%,11/36),the difference was statistically significant(P<0.05).Conclusion:Early clipping of intracranial aneurysms is effective in the treatment of intracranial aneurysms.It can effectively reduce the level of serum inflammatory factors,improve the neurological function and daily living ability of patients,and improve the prognostic effect.It is safe and worth popularizing.

关 键 词：早期颅内动脉瘤夹闭术 颅内动脉瘤 血清炎性因子 

分 类 号：R651.12[医药卫生—外科学]