学龄前儿童单纯性肥胖神经行为与血清IGF-1 GH水平的关系  

Relationship between Neurobehavioral Behavior of Simple Obesity and Serum IGF-1 and GH levels in Preschool Children

作　　者：黄纯 谈驰[1] 王新[1] 郑兵[1] 唐莎莎[1] HUANG Chun;TAN Chi;WANG Xin(Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Guangxi Nanning 530011,China)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《河北医学》2019年第2期211-215,共5页Hebei Medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题;(编号:Z2015421)

摘　　要：目的:分析单纯性肥胖学龄前儿童的神经行为问题发生率及血清胰岛素样生长因子-1变化(IGF-1)和生长激素(GH)水平,探讨单纯性肥胖儿童神经行为与血清IGF-1、GH的相关性。方法:选择南宁市某城区4~6岁学龄前儿童120例,将体重超过标准体重20%的儿童60例作为肥胖组,正常体重的儿童60例作为正常组。采用Achenbach儿童行为量表(CBCL)评估受试儿童心理及行为能力,采用酶联免疫吸附(ELISA)法检测受试儿童血清IGF-1、GH水平,分析CBCL评分与血清IGF-1、GH的关系。结果:肥胖组儿童神经行为问题异常发生率显著高于正常组(χ2=10.159,P=0.001),重度肥胖儿童神经行为异常发生率显著高于轻、中度肥胖儿童(χ2=4.516,P=0.034);肥胖组男童CBCL总评分显著高于正常组男童(P<0.05),女童CBCL总评分显著高于正常组女童(P<0.05);肥胖组儿童血清IGF-1水平均显著高于正常组儿童(P<0.05),血清GH水平均显著低于正常组儿童(P<0.05),肥胖程度越重血清IGF-1水平越高,GH水平越低;肥胖组CBCL评分与血清IGF-1呈显著正相关关系(r=0.622,P=0.000),与血清GH呈显著负相关关系(r= -0.489,P=0.012)。结论:学龄前儿童单纯性肥胖神经行为异常发生率升高,与肥胖严重程度及血清IGF-1水平升高、GH水平降低有关。Objective:To study the incidence of neural behavioral problems and the changes of serum insulin growth factor-1(IGF-1)and growth hormone(GH)levels of preschool children with simple obesity,and to explore the correlations between neural behavioral of children with simple obesity with the serum IGF-1 and GH.Methods:120 preschool children aged 4-6 years in a certain urban area of Nanning,60 children with body weight exceeding 20%of standard weight were selected as obese group,and 60 children with normal weight were used as normal group.The Achenbach Child Behavior Checklist(CBCL)was used to assess the psychological and behavioral abilities of the children,detection of serum IGF-1 and GH levels in children by enzyme-linked immunosorbent assay(ELISA),the relationships between CBCL score with serum IGF-1 and GH were analyzed.Results:The incidence rate of abnormal neural behavioral problems in obese group was significantly higher than that in the normal group(χ^2=10.159,P=0.001),the incidence rate of neural behavioral abnormalities in children with severe obesity was significantly higher than that in children with mild to moderate obesity(χ^2=4.516,P=0.034);the CBCL total score of boys in obesity group was significantly higher than that of boys in normal group(P<0.05),the CBCL total score of girls was significantly higher than that of girls in the normal group(P<0.05);the serum IGF-1 levels in obese children were significantly higher than those in the normal group(P<0.05),serum GH levels were significantly lower than those in normal group(P<0.05),the heavier the level of obesity,the higher the level of serum IGF-1,the lower the level of GH;the CBCL score is significantly positively correlated with the serum IGF-1 in obese group(r=0.622,P=0.000),was negatively correlated with serum GH level(r=-0.489,P=0.012).Conclusion:The incidence rate of neural behavioral abnormality in preschool children with simple obesity is increased,and is related to the severity of obesity,the increase of serum IGF-1 level and decrease of GH l

关 键 词：学龄前儿童 单纯性肥胖 神经行为 胰岛素样生长因子-1 生长激素 

分 类 号：R446.1[医药卫生—诊断学] R723.14[医药卫生—临床医学]