腹膜间皮瘤患者诊治中并发Wernicke脑病一例及文献复习  

Wernicke's Encephalopathy Onset during Diagnosis and Treatment of Peritoneal Mesothelioma:Report of One Case and Literature Review

作　　者：陈伽 陈丹[2] 李玥[2] 沈航[3] 李骥[2] 钱家鸣[2] CHEN Jia;CHEN Dan;LI Yue;SHEN Hang;LI Ji;QIAN Jiaming(Department of Internal Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院消化内科,北京100730 [3]中国医学科学院北京协和医学院北京协和医院神经内科,北京100730

出　　处：《中国医学科学院学报》2019年第1期129-133,共5页Acta Academiae Medicinae Sinicae

基　　金：北京协和医学院教学质量工程项目(2017zlgc0110)~~

摘　　要：Wernicke脑病(WE)是一种因维生素B1 (Vit B1)缺乏而引起的急性或亚急性中枢神经系统代谢性脑病,临床以眼肌麻痹、共济失调和意识障碍"三主征"为典型表现。北京协和医院收治了1名青年男性患者,以腹痛、发热起病,长期营养不良,诊治后期并发WE,主要表现为四肢抽搐、共济失调、谵妄等精神神经症状,给予Vit B1治疗后神经系统症状基本消失。初期患者原发病诊断未明,后经组织病理学证实为腹膜间皮瘤。Wernicke’s encephalopathy( WE),characterized by nystagmus and ophthalmoplegia,unsteadiness of stance and gait and mental-status changes,is an acute or subacute metabolic encephalopathy of the central nervous system resulting from Vitamin B1( VitB1) deficiency. A 29-year-old male patient was admitted to our hospital due to abdominal pain and fever. He remained chronically undernourished. He was complicated with WE at the late stage of diagnosis,mainly manifested as the convulsion of limbs,ataxia,and delirium. After treatment with VitB1,these neuropsychiatric symptoms were remarkably resolved. His primary disease was later pathologically confirmed as peritoneal mesothelioma.

关 键 词：WERNICKE脑病 维生素B1 腹膜间皮瘤 

分 类 号：R591.4[医药卫生—内科学]