MICA基因多态性与海南人群HBV易感关联性研究  

Association between MICA Gene Polymorphism and Susceptibility to HBV in Hainan Population

作　　者：柯艺文 陈纯静[1,2] 余艳艳 史婷婷 朱权[1] 陈恩 余平[1] KE Yiwen;CHEN Chunjing;YU Yanyan;SHI Tingting;ZHU Quan;CHEN En;YU Ping(Department of Immunology,College of Basic Medical Sciences,Central South University,Changsha 410078,Hunan,China;Changsha Medical College of Basic Medicine,Changsha 410219,Hunan,China;Department of Laboratory,First Affiliated Hospital of South China University,Hengyang 421001,Hunan,China)

机构地区：[1]中南大学基础医学院免疫学系,湖南长沙410078 [2]长沙医学院基础医学院,湖南长沙410219 [3]南华大学附属第一医院检验科,湖南衡阳421001

出　　处：《激光生物学报》2019年第1期54-57,71,共5页Acta Laser Biology Sinica

摘　　要：研究MICA等位基因多态性与海南人群HBV感染易感性之间的关联性。采用PCR-SSP和PCR-SBT方法对样本MICA等位基因的多态性进行检测。HBV感染患者中共检出10种MICA等位基因和5种MICA-STR等位基因,和对照组相比较,MICA*010、MICA-A5等位基因可能对HBV感染易感(MICA*010:OR=3. 88,95%CI:2. 19～6. 85,P=0. 000; MICA-A5:OR=1. 27,95%CI:0. 92～1. 77,P=0. 0068)。MICA*008/045基因型可能对HBV感染不易感,MICA*010/010纯合子基因型可能对HBV易感(MICA*008/045:OR=0. 09,95%CI:0. 01～1. 74,P=0. 0071; MICA*010/010:OR=4. 41,95%CI:1. 26～15. 46,P=0. 0106)。MICA等位基因多态性与海南人群HBV感染的易感性间存在关联性。To study the association between MICA allelic polymorphism and susceptibility to HBV infection in Hainan population.Polymorphism of MICA alleles in samples was detected by PCR-SSP and PCR method.A total of 10 MICA alleles and 5 MICA-STR alleles were detected in HBV infected patients.Compared with the control group,MICA 010 and MICA-A5 allele may be susceptible to HBV infection.For MICA*010:OR=3.88,95%CI:2.19~6.85,P=0.000,MICA-A5:OR=1.27,95%CI:0.92~1.77,P=0.0068.MICA*008/045 genotype may not be susceptible to HBV infection,and MICA 010/010 homozygous genotype may be susceptible to HBV infection.For MICA*008/045:OR=0.09,95%CI:0.01~1.74,P=0.0071;For MICA*010/010:OR=4.41,95%CI:1.26~15.46,P=0.0106.MICA allelic polymorphism was associated with susceptibility to HBV infection in Hainan population.

关 键 词：MICA基因 基因多态性 HBV感染 

分 类 号：R392.1[医药卫生—免疫学]