两种浓度人血清清蛋白制剂应用于慢性阻塞性肺疾病急性期伴低蛋白血症患者的疗效观察  

Observation on efficacy of two concentrations of human albumin preparations in patients with acute phase of chronic obstructive pulmonary disease complicating hypoproteinemia

作　　者：刘敏[1] 安志红[2] 徐小芳[1] 戴丽丽 朱春黎[1] 康圆超 LIU Min;AN Zhihong;XU Xiaofang;DAI Lili;ZHU Chunli;KANG Yuanchao(Department of Pharmacy,Shanghai Municipal Second People's Hospital,Shanghai 200011,China;Department of Intensive Care Unit,Shanghai Municipal Second People's Hospital,Shanghai 200011,China;Department of Respiration,Shanghai Municipal Second People's Hospital,Shanghai 200011,China)

机构地区：[1]上海市第二人民医院药剂科,上海200011 [2]上海市第二人民医院ICU科,上海200011 [3]上海市第二人民医院呼吸科,上海200011

出　　处：《重庆医学》2019年第3期411-413,419,共4页Chongqing medicine

基　　金：上海市药学会生物药品课题重点支持科研项目(2013-YY-01)

摘　　要：目的探讨5%和25%人血清清蛋白制剂应用于慢性阻塞性肺疾病(COPD)急性期合并低清蛋白血症患者的疗效。方法将90例血清清蛋白浓度小于35g/L的COPD急性期患者分为对照组(30例)、治疗A组(30例)和治疗B组(30例)。对照组进行常规医治及营养支持;在此基础上,治疗A组给予5%人血清清蛋白制剂250mL静脉滴注,每周3次,连续2周;治疗B组给予25%人血清清蛋白50mL,每周3次,连续2周。比较治疗前后3组患者的血清清蛋白水平、前清蛋白水平、急性生理学和慢性健康评分Ⅱ(APACHEⅡ)分值变化情况,分析3组间平均住院时间和平均住院费用总额的差异。结果治疗B组平均住院时间较对照组和治疗A组下降,治疗B组平均住院费用总额较对照组下降(P<0.05)。治疗A组血清清蛋白及前清蛋白水平治疗前后比较差异有统计学意义,且治疗后均高于对照组(P<0.05);B组治疗前后指标比较差异有统计学意义,治疗后血清清蛋白及前清蛋白水平高于对照组,APACHEⅡ分值低于对照组和治疗A组(P<0.05)。结论人血清清蛋白制剂可有效改善低蛋白血症症状,25%人血清清蛋白制剂有利于缩短平均住院时间和费用。Objective To investigate the treatment effect of 5% and 25% of human serum albumin preparations in the patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)complicating hypoproteinemia.Methods Ninety acute exacerbation of COPD patients with serum albumin concentration<35 g/L were divided into the control group(n=30),treatment group A(n=30)and treatment group B(n=30).The control group received the routine treatment and nutritional support.On the basis of the conventional treatment,the group A was given 5%human serum albumin preparation 250mL by intravenous drip,3 times a week,for continuous 2 weeks;the group B was given 25%human serum albumin 50mL,3 times a week,for continuous 2 weeks.The changes of serum albumin,prealbumin and APACHEⅡscores were compared between before and after treatment.The differences in the average hospitalization time and average hospitalization cost among the three groups were analyzed.Results The average length of hospital stay in the group B was significantly decreased compared with the control group and group A.The average hospitalization cost in the group B was significantly reduced compared with the control group(P<0.05).The serum albumin and prealbumin values in the group A had statistically significantly difference between before and after treatment,and it was higher than those in the control group after treatment(P<0.05).The indexes in the group B had statistically significant difference between before and after treatment.The serum albumin level and prealbumin level after treatment were higher than those in the control group,and the APACHEⅡ score after treatment was lower than that in the control group and group A(P<0.05).Conclusion Human albumin preparation can effectively improve the symptoms of hypoproteinemia,and 25% of human albumin preparation is beneficial to shorten the average hospitalization time and cost.

关 键 词：人血清清蛋白 慢性阻塞性肺病急性期 低蛋白血症 

分 类 号：R969.4[医药卫生—药理学]