左氧氟沙星在复治涂阳肺结核治疗方案中的效果分析  

Comparative analysis of the effect of levofloxacin in the treatment of retreated smear-positive pulmonary tuberculosis

作　　者：郭洋[1] 刘宁[1] 白国峰[1] 方强 GUO Yang;LIU Ning;BAI Guofeng;FANG Qiang(First Department of Respiratory, Shenyang Tenth People's Hospital, Shenyang 110044, China)

机构地区：[1]沈阳市第十人民医院呼吸一科,辽宁沈阳110044

出　　处：《中国现代医生》2019年第3期41-43,共3页China Modern Doctor

摘　　要：目的探讨左氧氟沙星在复治涂阳肺结核治疗方案中的临床效果。方法对2016年1月～2018年1月在我院治疗的120例复治涂阳肺结核患者随机分组,对照组患者给予常规治疗,实验组患者应用左氧氟沙星联合治疗,观察比较两组患者治疗效果、CT疗效、痰菌转阴率和不良反应发生率差异。结果实验组总有效率为98.33%,明显高于对照组(85.00%),差异有统计学意义(P<0.05);实验组CT治疗总有效率为96.66%,高于对照组(78.33%),差异有统计学意义(P<0.05);实验组痰菌转阴率为95.00%,高于对照组(63.33%),差异有统计学意义(P<0.05),实验组不良反应发生率为8.33%,低于对照组(11.67%),但差异无统计学意义(P>0.05)。结论针对复治涂阳肺结核患者应用左氧氟沙星治疗可提高治疗效果及胸部CT疗效,疗效显著,安全性高,值得推广应用。Objective To explore the clinical effect of levofloxacin in the treatment of re-treated smear-positive pulmonary tuberculosis. Methods 120 patients with re-treated smear-positive pulmonary tuberculosis who were treated in our hospital from January 2016 to January 2018 were randomized. Patients in the control group were given routine treatment. Patients in the experimental group were treated with levofloxacin. The differences of treatment effect, CT curative effect, sputum negative rate and adverse reaction rate were compared between the two groups. Results The total effective rate of the experimental group was 98.33%, which was significantly higher than that of the control group(85.00%). The difference was statistically significant(P<0.05). The total effective rate of CT treatment in the experimental group was 96.66%, higher than that of the control group(78.33%). The difference was statistically significant(P<0.05). The sputum negative rate in the experimental group was 95.00%, higher than that in the control group(63.33%), and the difference was statistically significant(P<0.05). The adverse reaction rate was 8.33% in the experimental group, lower than that in the control group(11.67%), but the difference was not statistically significant(P>0.05). Conclusion The application of levofloxacin in the treatment of patients with re-treated smear-positive pulmonary tuberculosis can improve the therapeutic effect and the chest CT curative effect. The clinical effect is remarkable and the safety is high, which is worthy of popularization and application.

关 键 词：左氧氟沙星 复治涂阳肺结核 痰菌转阴 治疗方案 

分 类 号：R521[医药卫生—内科学]