检测凝血功能对COPD急性加重期患者的意义研究  

Study on significance of coagulation function test in patients with acute exacerbation of COPD

作　　者：胡瑛 秦庆 吕永强[1] HU Ying;QIN Qing;LYU Yong-qiang(Department of Clinical Laboratory, 210 Hospital of the Chinese People’s LiberationArmy, Dalian 116000, China)

机构地区：[1]中国人民解放军第210医院检验科,116000

出　　处：《中国现代药物应用》2019年第4期12-13,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨检测凝血功能对慢性阻塞性肺疾病(COPD)急性加重期患者的意义。方法 80例COPD急性加重期患者为试验组, 80例COPD稳定期患者为对照组。检测并比较两组患者的血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、血小板(PLT)、D-D二聚体(D-D)水平。结果试验组患者的PT(13.7±1.5)s、APTT(39.3±18.2)s均长于对照组的(12.3±1.4)、(32.2±18.3)s, FIB(4.6±1.0)g/L、D-D(1.3±0.2)mg/L、PLT(208.6±56.2)×109/L均高于对照组的(3.1±1.1)g/L、(0.6±0.1)mg/L、(188.0±56.1)×109/L,差异均具有统计学意义(P<0.05)。结论 COPD急性加重期患者处于高凝状态,急性加重期更容易导致血栓形成,检测凝血功能有利于监测COPD的疾病变化。Objective To discuss the significance of coagulation function test in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods There were 80 patients with acute exacerbation of COPD as experimental group, and 80 patients with stable COPD as control group. Detection and comparison were made on plasma prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), platelet(PLT), D-D dimer(D-D) levels between the two groups. Results The experimental group had PT as(13.7±1.5) s and APTT as(39.3±18.2) s, which were all longer than(12.3±1.4) and(32.2±18.3) s in the control group, and higher FIB as(4.6±1.0) g/L, D-D as(1.3±0.2) mg/L and PLT as(208.6±56.2)×10~9/L than(3.1±1.1) g/L,(0.6±0.1) mg/L and(188.0±56.1)×10~9/L in the control group. Their difference was statistically significant(P<0.05). Conclusion Patients with acute exacerbation of COPD are in hypercoagulable state, which is more likely to lead to thrombosis. Detection of coagulation function is conducive to monitoring the disease changes of COPD.

关 键 词：凝血功能 慢性阻塞性肺疾病 急性加重期 

分 类 号：R563.9[医药卫生—呼吸系统]