全身播散性偶发分枝杆菌病1例报告并文献复习  

Systemic disseminated Mycobacterium fortuitum infection:one case report and literature review

作　　者：罗丽莎[1] 罗百灵[1] 唐薇[1] 邓双林子 胡新月[1] 牛瑞超[1] 胡成平[1] 冯俊涛[1] LUO Li-sha;LUO Bai-ling;TANG Wei;DENG Shuang-linzi;HU Xin-yue;NIU Rui-chao;HU Cheng-ping;FENG Jun-tao(Department of Respiratory Disease, Key Department of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008, China)

机构地区：[1]中南大学湘雅医院呼吸内科国家呼吸疾病临床学研究中心核心单位,湖南长沙410008

出　　处：《中国感染控制杂志》2019年第2期158-162,共5页Chinese Journal of Infection Control

摘　　要：目的探讨偶发分枝杆菌引起全身播散性感染的临床特点,以提高诊断率及对该病的认识。方法报告全身播散性偶发分枝杆菌感染1例,并结合相关文献进行分析。结果患者全身多系统累及(包括肺部、淋巴结、皮肤、关节),淋巴结组织培养偶发分枝杆菌阳性,给予克拉霉素+左氧氟沙星+利奈唑胺治疗,病情缓解。结论偶发分枝杆菌引起全身播散性感染罕见,其机制可能与患者存在GATA2的缺乏和IFN-γ自身抗体有关,确诊主要依靠病理学及微生物学检查,但阳性率偏低,诊断困难。Objective To explore the clinical characteristics of systemic disseminated infection caused by Mycobacterium fortuitum(M.fortuitum),and improve the diagnostic rate and understanding of the disease.Methods One case of systemic disseminated M.fortuitum infection was reported,and analyzed in combination with relevant literatures.Results Patient was with multiple systemic involvement(including lung,lymph node,skin,joint),lymph node tissue culture was positive for M.fortuitum,patient was given clarithromycin+levofloxacin+linezolid for treatment,disease was remitted.Conclusion Systemic disseminated M.fortuitum infection is rare,and patient with GATA2 deletion and IFN-γautoantibody may be a potential mechanism,diagnosis is mainly based on patholo-gical morphology and microbiological detection,but positive rate is low,diagnosis is difficult.

关 键 词：非结核分枝杆菌 播散性非结核分枝杆菌病 偶发分枝杆菌 播散性感染 

分 类 号：R378.91[医药卫生—病原生物学]