超声引导下腹横肌平面麻醉对无张力疝修补术患者血清犬尿喹啉酸和色氨酸水平的影响  

Effect of ultrasound-guided local anesthesia on the serum levels of kynurenie acid and tryptophan in patients undergoing tension-free hernioplasty

作　　者：金秋艳 田秋阁 刘亚宁 崔安宁 高永维 荣银娈 李建全 冯小波 刘鹏飞 杨维艳 王振永 Jin Qiuyan;Tian Qiuge;Liu Yaning;Cui Anning;Gao Yongwei;Rong Yinluan;Li Jianquan;Feng Xiaobo;Liu Pengfei;Yang Weiyan;Wang Zhenyong(Department of General Surgery,The People's Hospital of Renqiu,Renqiu 062550,China;Department of Anesthesiology,The People's Hospital of Renqiu,Renqiu 062550,China;Department of General Surgery,The People’s Hospital of Cangzhou,Cangzhou 061000,China)

机构地区：[1]河北省任丘市人民医院普外外科,任丘062550 [2]河北省任丘市人民医院麻醉科,任丘062550 [3]河北省沧州市中心医院普外一科,任丘061000

出　　处：《广西医科大学学报》2019年第2期236-239,共4页Journal of Guangxi Medical University

摘　　要：目的:研究超声引导下腹横肌平面麻醉(TAPB)对无张力疝修补术患者血清犬尿喹啉酸(KYNA)和色氨酸(TRP)水平的影响。方法:选择2014年1月至2017年1月本院收治的100例单侧腹股沟斜疝患者。按随机数字表法分为观察组和对照组,每组50例。对照组实施全身麻醉,观察组在对照组的基础上行双侧超声引导下TAPB。比较两组术后疼痛视觉模拟量表(VAS)评分,血清KYNA、TRP、干扰素(IFN)-γ和白介素(IL)-6水平及不良反应发生率。结果:观察组静息状态和咳嗽时的VAS评分及血清KYNA、IFN-γ、IL-6水平均显著低于对照组,TRP水平显著高于对照组(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:超声引导下TAPB能够减轻无张力疝修补术患者术后疼痛,且对患者术后血清KYNA、TRP水平影响小,安全性好。Objective:To explore the ultrasound-guided local anesthesia on serum kynurenie acid(KYNA) and tryptophan(TRP) levels in patients undergoing tension-free hernioplasty. Methods:A total of 100 patients with unilateral inguinal hernia in our hospital from January 2014 to January 2017 were selected,and randomized to receive either general anaesthesia only(control group,50 cases) or combined with bilateral ultrasound-guided transverse abdominal muscle plane block(observation group,50 cases).The visual analogue scale(VAS) score and the serum levels of KYNA,TRP,interferon(IFN)-γ and interleukin(IL)-6 as well as the incidence of adverse reactions were detected and compared. Results:The resting and cough VAS scores and the serum levels of KYNA,IFN-γ and IL-6 in the observation group were significantly lower than those in the control group,while the TRP level was notably higher( P <0.05).There was no significant difference in the incidence of adverse reactions between the two groups( P >0.05). Conclusion:Ultrasound-guided local anesthesia could relieve pain in patients with tension-free hernioplasty and had less impact on the levels of KYNA and TRP,and was safe.

关 键 词：超声引导下腹横肌平面麻醉 无张力疝修补术 犬尿喹啉酸 色氨酸 

分 类 号：R656.21[医药卫生—外科学]