基于超声组织定征技术的脂肪肝无创检测  

Noninvasive Detection of Fatty Liver Based on Ultrasound Tissue Characterization Techniques

作　　者：丁琪瑛[1] 周著黄[2] 吴水才[2] 崔博翔 DING Qiying;ZHOU Zhuhuang;WU Shuicai;TSUI PoHsiang(Ultrasound Room,University Hospital,Beijing University of Technology,Beijing 100124,China;College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China;College of Medicine,Chang Gung University,Taoyuan Taiwan 33302,China)

机构地区：[1]北京工业大学校医院超声室,北京100124 [2]北京工业大学生命科学与生物工程学院,北京100124 [3]台湾长庚大学医学院,台湾桃园33302

出　　处：《中国医疗设备》2019年第3期155-159,共5页China Medical Devices

基　　金：国家自然科学基金项目(11804013);国家自然科学基金项目(61871005);北京市自然科学基金项目(4184081)

摘　　要：早期检测脂肪肝对于及时治疗和预防肝硬化具有重要意义。本文对基于超声组织定征技术的脂肪肝无创检测方法进行综述,主要包括超声弹性成像技术和定量超声技术(超声衰减系数、包络统计、背向散射系数、谱参数、散射子特性)。系统阐述了各方法评估脂肪肝的原理和研究现状。主要结论包括:①超声弹性成像评估脂肪肝的临床价值存在争议,需进一步研究明确;②定量超声检测不同程度脂肪肝的性能有待明确和提高。提出以下未来发展方向:①各种超声组织定征技术检测不同程度脂肪肝的性能对比研究,以明确各种超声组织定征技术检测不同程度脂肪肝的性能和特点;②融合多种超声组织定征技术的脂肪肝检测方法研究,以提高不同程度脂肪肝检测的性能;③探索能有效评估不同程度脂肪肝的超声组织定征新技术。Early detection of fatty liver is of great importance for timely treatment and prevention of liver cirrhosis. In this paper, noninvasive detection methods of fatty liver based on ultrasound tissue characterization were reviewed, including ultrasound elastography and quantitative ultrasound techniques (ultrasound attenuation coefficient, envelope statistics, backscattering coefficient, spectral parameter, scatterer property). The principles and research status of various methods for evaluating fatty liver were systematically expounded. The main conclusions included two aspects. First, the clinical value of ultrasound elastography in evaluating fatty liver was controversial, which needed to be further studied. Secondly, the performance of quantitative ultrasound in detecting fatty liver in different degrees needs to be clarified and improved. The future development direction of this research field mainly includes three aspects. First, a comparative study on the performance of various ultrasonic tissue characterization techniques in detecting different degrees of fatty liver will be conducted to clarify the performance and characteristics of various ultrasonic tissue characterization techniques in detecting different degrees of fatty liver. Secondly, the method of fatty liver detection will be studied by combining various ultrasonic tissue characterization techniques to improve the performance of different degrees of fatty liver detection. Third, a new technique of ultrasonography for the determination of fatty liver will be explored.

关 键 词：超声组织定征 脂肪肝 无创检测 超声背向散射信号 超声射频信号 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]