宫外孕Ⅱ号方加减方治疗异位妊娠的疗效和安全性研究  

Study on efficacy and safety of ectopic pregnancy Ⅱ prescription on ectopic pregnancy

作　　者：郑春梅[1] 刘晓峰[1] ZHENG Chunmei;LIU Xiaofeng(Department of Pharmacy,Maternity and Child Healthcare Hospital of Shenzhen NanshanDistrict,Guangdong Shenzhen 518000,China)

机构地区：[1]深圳市南山区妇幼保健院药剂科,广东深圳518000

出　　处：《药学服务与研究》2019年第1期29-31,共3页Pharmaceutical Care and Research

摘　　要：目的:研究宫外孕Ⅱ号方加减方单独治疗异位妊娠的疗效和安全性。方法:选取深圳市南山区妇幼保健院2015年12月至2017年12月的160例异位妊娠患者,随机分为两组。对照组予甲氨蝶呤治疗,首次肌内注射50mg/m2,7d后复查,根据复查情况使用不同剂量的甲氨喋呤,隔一天复查一次;治疗组予宫外孕Ⅱ号方加减方治疗,1剂/d,连续服用7d以上。对两组患者治疗后的血β-人绒膜促性腺激素(β-HCG)水平及恢复正常值的时间、附件区域肿块大小、消退时间、住院时间、治疗有效率和药品不良反应(ADRs)发生率进行比较。结果:治疗组的治疗有效率显著高于对照组,差异有统计学意义(95.0%vs 83.8%,P<0.05)。治疗组的ADRs发生率显著低于对照组,差异有统计学意义(6.3%vs 20.0%,P<0.05)。治疗7d后,治疗组患者的血β-HCG水平[(5.13±1.82)ng/ml vs (7.62±2.30)ng/ml]、肿块大小[(1.05±0.37)cmvs(1.87±0.62)cm]、血β-HCG恢复正常值的时间[(12.27±2.59)d vs(15.31±3.22)d]、肿块消失时间[(14.87±2.31)d vs(20.53±3.47)d]、住院时间[(13.59±3.11)d vs(19.62±2.57)d]均显著低于对照组,差异有统计学意义(P<0.05,P<0.01)。结论:宫外孕Ⅱ号方加减方治疗异位妊娠可提高治疗有效率,加快肿块消除速度,且ADRs发生率低,但可能延长个别患者的阴道出血时间,临床上需注意合理应用。Objective:To study the efficacy and safety of ectopic pregnancyⅡprescription as a monotherapy in the treatment of ectopic pregnancy.Methods:160patients with ectopic pregnancy from December 2015to December 2017in the Maternity and Child Healthcare Hospital of Shenzhen Nanshan District were included and randomly divided into two groups.The patients in the control group were treated with methotrexate at a dosage of 50mg/m2 intramuscularly injected for the first time. Seven days later,the patients were reexamined.Different doses of methotrexate were given according to the reexamination results,and then,the patients were reexamined every other day.Patients in the treatment group were treated with ectopic pregnancyⅡ prescription,1dose per day,for a succession of more than 7days.The blood level and recovery time to normal value of β-human chorionic gonadotropin(β-HCG),lump size,lump disappearance time,hospitalization days,treatment effective rate and rate of adverse drug reactions(ADRs)were compared between the two groups.Results:Therapeutic efficacy of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(95.0%vs 83.8%, P<0.05).The rate of ADRs in the treatment group was significantly lower than that in the control group,also with statistical significance(6.3%vs 20.0%,P<0.05).Seven days after treatment,the blood level ofβ-HCG [(5.13±1.82)ng/ml vs (7.62±2.30)ng/ml],lump size[(1.05±0.37)cmvs(1.87±0.62)cm],recovery time to normal value ofβ-HCG[(12.27± 2.59)d vs(15.31±3.22)d],lump disappearance time[(14.87±2.31)d vs(20.53±3.47)d],hospitalization days[(13.59± 3.11)d vs(19.62±2.57)d]in the treatment group were significantly lower or less than those in the control group(P<0.05, P<0.01).Conclusion:The treatment of ectopic pregnancy with ectopic pregnancyⅡprescription could improve effective rate, accelerate lump disappearance,and lower the rate of ADRs.However,it might prolong the vaginal bleeding of certain patients, so attention should

关 键 词：宫外孕Ⅱ号方 异位妊娠 疗效 安全性 

分 类 号：R984[医药卫生—药品]