替加环素致胰腺炎的回顾性分析  

Retrospective analysis of pancreatitis induced by tigecycline

作　　者：周峰[1] 吴小燕 郭晓辉[1] ZHOU Feng;WU Xiaoyan;GUO Xiaohui(Department of Pharmacy,Hainan Branch Hospital of Chinese PLA General Hospital,Hainan Sanya 572013,China)

机构地区：[1]解放军总医院海南分院药剂科,海南三亚572013

出　　处：《药学服务与研究》2019年第1期59-62,共4页Pharmaceutical Care and Research

摘　　要：目的:探究替加环素导致胰腺炎的发生规律,促进替加环素临床合理应用。方法:检索国内外有关替加环素不良反应的文献报道,整理分析相关信息。结果:共检索到13例独立文献报道,病人多为男性,老年居多。13例病例中7例采用常规替加环素剂量治疗,药物所致胰腺炎均表现恶心、呕吐等症状,同时伴随血清指标变化,停药并对症治疗后,2～15d内多数症状缓解。结论:替加环素与胰腺炎存在明确相关性,临床使用中要严密监控血清指标,同时需格外关注患有心血管和自身免疫性疾病的病人。Objective:To explore the regular pattern of the incidence of pancreatitis induced by tigecycline,so as to promote rational application of tigecycline clinically.Methods:Reports on adverse drug reactions of tigacycline both at home and abroad were collected and analyzed in the study.Results:A total of 13independent literature reports were retrieved and reviewed. Most of the patients were male,and the majority of the patients were elderly people.Of the 13cases,7were treated with conventional dose of tigecycline.Pancreatitis caused by drugs all displayed symptoms of nausea and vomiting,accompanied by changes in serum indexes.After drug withdrawal and expectant treatment,most symptoms were relieved 2-15days later. Conclusion:There is a clear correlation between tigecycline and pancreatitis.Serum indicators should be closely monitored in clinical practice,and special attention should be paid to those patients with cardiovascular and autoimmune diseases.

关 键 词：替加环素 胰腺炎 药物副反应报告系统 

分 类 号：R994.11[医药卫生—毒理学] R978.14[医药卫生—药学]