淀粉样变性的消化系统表现  

Gastrointestinal manifestations of amyloidosis

作　　者：齐凤祥[1] 张颖[1] 季英兰[1] 江勇[1] Feng-Xiang Qi;Ying Zhang;Ying-Lan Ji;Yong Jiang(Department of Gastroenterology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院消化科,天津市300211

出　　处：《世界华人消化杂志》2019年第4期260-266,共7页World Chinese Journal of Digestology

摘　　要：淀粉样变性是指具有β片层结构且刚果红染色阳性的淀粉样纤维结构物质在细胞外沉积而导致的一组疾病,目前仍是一个通过组织学做出诊断的疾病,活检组织刚果红染色呈砖红色,偏光显微镜下为苹果绿双折光是淀粉样变性的诊断性特征.系统性淀粉样变性患者,常出现消化道症状,表现形式复杂多样,包括巨舌、吞咽困难、腹痛、出血、便秘、腹泻、吸收不良和不同程度的消化道出血.淀粉样变性临床症状不典型,容易漏诊,导致治疗延迟.本文就淀粉样变性累及消化系统的临床表现、内镜特征及相关治疗进展进行综述.Amyloidosis is a group of diseases which are caused by the extracellular deposition of amyloid fibrils,which have a beta lamella structure and are positive for Congo red staining.The diagnosis of amyloidosis still relies on histology.Brick red coloration in Congo red staining of biopsy tissue and apple green double refraction under a polarizing microscope are diagnostic features of amyloidosis.Patients with systemic amyloidosis often exhibit gastrointestinal symptoms,which have complicated patterns of manifestations,including giant tongue,dysphagia,constipation,diarrhea,abdominal pain,bleeding,malabsorption,and different levels of gastrointestinal bleeding.Clinical symptoms of amyloidosis are atypical and easy to be misdiagnosed,which often causes delayed treatment.In this review,we will briefly introduce the clinical and endoscopic features of gastrointestinal manifestations of amyloidosis as well as its treatment.

关 键 词：胃肠道淀粉样变性 淀粉样变性 原发性淀粉样变性 继发性淀粉样变性 

分 类 号：R597.2[医药卫生—内科学]