气相色谱-质谱法测定美白祛斑类化妆品中的苯酚和氢醌  

Determination of Phenol and Hydroquinone in Whitening and Freckle-removing Cosmetics by GC-MS

作　　者：翟宇 尚博扬 黄青[2] 杨静 ZHAI Yu;SHANG Boyang;HUANG Qing;YANG Jing(Ningxia Institute for Drug Control,Yinchuan 750004,China;Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏回族自治区药品检验研究院,银川750004 [2]宁夏医科大学,银川750004

出　　处：《宁夏医科大学学报》2019年第1期40-43,共4页Journal of Ningxia Medical University

基　　金："宁夏药物创制与仿制药研究重点实验室"开放课题

摘　　要：目的建立测定美白祛斑类化妆品中苯酚和氢醌的气相色谱-质谱方法。方法样品经甲醇超声提取,离心,微孔滤膜过滤,采用气相色谱-质谱法法测定。结果苯酚和氢醌在10～200μg·mL^(-1)浓度范围内线性良好(r=0.9999),检出限为氢醌0.01mg·kg^(-1)、苯酚0.03mg·kg^(-1),平均回收率为88.7%～104.6%,RSD为2.15%～4.09%。结论本法简便快速,结果准确可靠,可用于美白祛斑类化妆品中苯酚和氢醌的测定。Objective To establish a GC-MS method for determination of phenol and hydroquinone in whitening and freckle-removing cosmetics. Methods The samples were extracted with methanol in ultrasonic bath, centrifuged and filtered by microporous membrane, and then analyzed by GC-MS. Results The calibration curves of phenol and hydroquinone in the range of 10-200μg·mL^-1(r=0.9999) showed good linear relationships,and the average recoveries were 88.7%-104.6% with relative standard deviations of 2.15%-4.09%. Conclusion The GC-MS method is simple and rapid, and the result is accurate and reliable.

关 键 词：苯酚 氢醌 气相色谱-质谱法 化妆品 

分 类 号：O657.3[理学—分析化学]